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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 343-345 
    ISSN: 1432-1440
    Keywords: EDTA anticoagulated blood ; capillary blood ; blood platelets ; platelet phagocytosis ; thrombocytopenia ; polymorphonuclear leukocytes ; EDTA-Blut ; Capillarblut ; Thrombocyten ; Thrombocytenphagocytose ; Thrombocytopenie ; neutrophile Granulocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei zwei Patienten fiel im EDTA-Blutausstrich eine außergewöhnliche Adhärenz von Blutplättchen an Granulocyten auf. In den gleichen Blutproben wurden verminderte Thrombocytenwerte gezählt. Diese Granulocyten-Plättchen-Rosetten treten sehr selten, nur in vitro im EDTA-Blut und an neutrophilen Granulocyten auf. Eine Plättchenphagocytose durch Granulocyten konnte nachgewiesen werden. Die auslösende Ursache ist unbekannt. Zur Vermeidung eines falschen Thrombocytopenie-Befundes sollte bei Beobachtung von Granulocyten-Plättchen-Rosetten eine Kontrolle der Thrombocytenzahl im Capillarblut herangezogen werden.
    Notes: Summary Extraordinary platelet adherence to polymorphonuclear leukocytes was seen in EDTA anticoagulated blood smears of two patients. From the same blood samples platelets were greatly reduced in number. Platelet satellitism (granulocyte platelet rosettes) is a rare phenomenon in vitro, only seen in EDTA anticoagulated blood, and the platelets surrounded polymorphonuclear leukocytes only. Phagocytosis of platelets was also observed. The cause of platelet satellitism is unknown. Capillary blood should be investigated in order to prevent a false thrombocytopenia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 166-169 
    ISSN: 1434-4726
    Keywords: Cisplatin ; Drug resistance ; Glutathione ; γ-Glutamyltranspeptidase ; Head and neck cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Drug resistance is a major problem in chemotherapy of squamous cell head and neck cancers (SCHNC). Since glutathione (GSH) plays a crucial role in mediating tumor cell resistance against various toxic insults, GSH metabolism in SCHNC xenografts was investigated. Xenografts from lymph node metastases contained markedly higher GSH concentrations compared with those derived from the corresponding primary lesions. After subcurative chemotherapy with cisplatin (DDP), a significant increase of both GSH levels and γ-glutamyltranspeptidase activity (γ-GT) was gained in tumor HT1M. Tumor HT3M showed high concentrations of GSH and γ-GT, although these latter concentrations did not increase following chemotherapy with DDP. These findings suggest a possible impact of GSH metabolism on both the formation of metastases and the phenomenon of drug resistance in SCHNC.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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