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  • 1
    ISSN: 1572-8773
    Keywords: EDTMP ; formation constants ; protonation constants ; samarium ; speciation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract 153Sm-EDTMP (ethylenediaminetetra(methylenephosphonic) acid) is of considerable interest as a bone therapeutic radiopharmaceutical but its properties in solution are not yet well characterized. The protonation constants of EDTMP and the formation constants of the complexes of Sm-EDTMP have accordingly been measured potentiometrically by glass electrode titrations at 25°C in 0.15 M NaCl. Six protonation constants (log β011 = 9.638, log β012 = 17.330, log β013 = 23.597, log β014 = 28.636, log β015 = 31.501, log β016 = 32.624) and the formation constants of the [Sm(EDTMP)H-1]6- (log β11-1 = 4.865), [SmEDTMP]5- (log β110 = 12.018), [Sm(EDTMP)H]4- (log β111 = 17.892) and [Sm(EDTMP)H2]3- (log β112 = 23.437) complexes were determined. Computer simulations indicate that the [SmEDTMP]5- and the hydroxy [Sm(EDTMP)H-1]6- species are the major Sm(III) complexes formed in blood plasma, which explains the high degree of localization in the kidney and urine observed in biodistribution studies. Calcium ions are probably the maior competitor for EDTMP in blood plasma. As the presence of secondary skeletal metastases results in a high rate of bone turnover, it is possible that the high concentration of calcium at these sites encourages localization of 153Sm-EDTMP.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1327
    Keywords: Key words Raman microscopy ; Biomineralization ; Chiton ; Mollusc ; Iron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract  In situ Raman spectroscopy, in combination with energy dispersive spectroscopy, has been used for the first time to determine the identities and locations, at the micron level, of mineral phases present in single chiton teeth that have been extensively mineralized. At the later stages of development the major lateral teeth of the chiton Acanthopleura hirtosa show characteristic spectroscopic evidence for the presence of lepidocrocite (γ-FeOOH), magnetite (Fe3O4), and an apatitic calcium phosphate. Goethite (α-FeOOH) and ferrihydrite (5 Fe2O3·9 H2O), which have been detected previously in teeth at the early stages of mineralization, were not detected in this mature tooth. The spatial distribution of these phases was determined, providing evidence for the presence of a discrete layer of lepidocrocite between the magnetite and apatite regions, illustrating the complexity of the biomineralization process. The technique of laser Raman microscopy is shown to be ideal for the examination of small biomineralized structures in situ, such as chiton teeth.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    HNO 48 (2000), S. 527-532 
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Laryngitis gastrica ; Omeprazol ; Key words Laryngitis gastrica ; Omeprazol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract We treated 64 patients with the diagnosis of laryngitis gastrica with Antra (Omeprazol) in doses of 10, 20, and 40 mg. To determine the success of the therapy, pH monitoring of the esophagus and hypopharynx, the voice status and measurement of vocal penetrating capacity were used. The results prove that a 20-mg dose of Antra is suitable for the therapy of laryngitis gastrica with a high rate of success. Problems which arose during the investigation, consequent changes of the original concept of the project as well as new aspects and questions which resulted from this are discussed with respect to further investigation.
    Notes: Zusammenfassung In einem Therapieversuch werden 64 Patienten mit der Diagnose Laryngitis gastrica mit Antra (Omeprazol) in unterschiedlicher Dosierung, 10, 20, und 40 mg, behandelt. Zur Beurteilung des Therapieerfolgs werden die pH-Metrie des Ösophagus und Hypopharynx, die Laryngoskopie, Mikrostroboskopie, der Stimmstatus und die Messung der stimmlichen Durchdringungsfähigkeit herangezogen. Das Ergebnis zeigt, dass mit Antra (Omeprazol) in der Dosierung 2-mal 20 mg ein geeignetes Medikament zur Therapie der Laryngitis gastrica mit hoher Erfolgsquote zur Verfügung steht. Es werden Probleme bei der Durchführung der Studie, dadurch bedingte Abweichungen von der ursprünglichen Konzeption des Projekts, sowie daraus resultierende neue Gesichtspunkte und Fragestellungen für weitere Untersuchungen diskutiert.
    Type of Medium: Electronic Resource
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