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  • Early organogenesis  (1)
  • Endometriosis  (1)
  • Maternal diabetes  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Embryonic growth impaired by maternal hypoglycemia during early organogenesis in normal and diabetic rats (1994)
    Springer
    Acta diabetologica 31 (1994), S. 141-146 
    Details
    ISSN: 1432-5233
    Schlagwort(e): Hypoglycemia ; Maternal diabetes ; Rat embryo ; Early organogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of maternal hypoglycemia on early organogenesis was studied in normal and diabetic rats. Female Wistar rats were made diabetic by an intravenous injection of streptozotocin (45 mg/kg) 2–3 weeks before conception. On day 9.5 or 10.5 of embryo development, both control and diabetic dams received saline or Actrapid human insulin (400 mU/rat) intraperitoneally after 19-h starvation. The fasting plasma glucose levels in diabetic dams decreased from approximately 23 to 8 mM. Hypoglycemia as low as 3.5 mM was maintained for 60 min in insulin-treated mother rats. Pregnancy was terminated on day 11.6 of embryo development. A significant growth retardation was found in diabetic embryos as compared with normal embryos. Maternal hypoglycemia lowered the DNA content in normal but not diabetic embryos, while the teratogenic effect of maternal hypoglycemia was not pronounced in either normal or diabetic embryos. These data may suggest that maternal hypoglycemia in vivo in early pregnancy influences the embryogenesis but not teratogenesis of rat embryos.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00570368
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Coexisting clear cell adenocarcinoma and squamous cell carcinoma arising from ovarian endometriosis (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 405-409 
    Details
    ISSN: 1437-7772
    Schlagwort(e): Key words Ovary ; Clear cell adenocarcinoma ; Squamous cell carcinoma ; Endometriosis ; Pathology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A case of clear cell adenocarcinoma and squamous cell carcinoma coexisting in the ovary is presented. These two malignancies were adjacent but were not admixed, and ovarian endometriosis was confirmed concurrently. The clear cell adenocarcinoma was contiguous to monolayered glandular cells with cytological and architectural atypia, while squamous metaplasia with cellular atypia was observed adjacent to the squamous cell carcinoma. We concluded that these two malignancies arose independently from ovarian endometriosis. To our knowledge, this is the first report of such a case.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00012071
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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