ISSN:
1432-1238
Keywords:
Key words Oleic acid
;
Lung injury
;
Respiratory distress
;
Albumine
;
Bolus injections
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: Development of a stable model of respiratory distress in pigs with oleic acid, fulfilling clinical criteria of the adult respiratory distress syndrome (ARDS). Design: Eight pigs (9.1±0.7 kg) were anesthetized with pentobarbital, paralyzed with tubocurarine and mechanically ventilated with an FIO2 of 0.6, an I:E ratio of 2:3 and a PEEP of 0.2 kPa. Oleic acid (dissolved 1:1 in 96% alcohol) was administered in a series of multiple injections of 0.1 ml until P aO2 was lower than 8 kPa. Measurements and results: Careful titration of the oleic acid injections on guidance of the P aO2 established a reproducible respiratory distress (P aO2=7.3±0.8 kPa), in which gas exchange and hemodynamic variables were stable for at least 4 h. The number of oleic acid injections (22±11, mean and SD) varied between the animals. Conclusions: With the use of multiple injections of oleic acid, a stable model of early respiratory distress in pigs can be achieved, in spite of individual differences in sensitivity. Such a stable model allows for a diversity of studies on early respiratory distress.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01700456
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