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  • 1
    Electronic Resource
    Electronic Resource
    Effect on blood pressure of intravenous administration of a phospholipid renin preinhibitor and its active form in renal hypertensive rats (1973)
    Springer
    Pflügers Archiv 341 (1973), S. 113-120 
    Details
    ISSN: 1432-2013
    Keywords: Phospholipid Renin Preinhibitor ; Lysophospholipid Renin Inhibitor ; Renal Hypertensive Rats ; Effect on Blood Pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been evaluated the effect of acute intravenous administration of a phospholipid renin preinhibitor and its active form (lysophospholipid) in rats rendered hypertensive by unilateral renal ischemia, by continuous infusion of homologous renin and in normal control rats. Both the substances have no effect on blood pressure in normal rats. In rats rendered hypertensive by unilateral renal ischemia or by continuous infusion of homologous renin, injection of inactive phospholipid does not lower blood pressure, while the same quantity of active lysophospholipid brings about a significant reduction. This observation suggest either the absence of circulating specific phospholipase(s), or their non activation of the preinhibitor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587318
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A possible role of the kidney in activating a renin preinhibitor (1975)
    Springer
    Research in experimental medicine 166 (1975), S. 201-207 
    Details
    ISSN: 1433-8580
    Keywords: Phospholipid renin preinhibitor ; Conversion to lysophospholipid renin inhibitor ; Human plasma ; Human kidney homogenate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to verify the possibility than human plasma and kidney can activate a renin preinhibitor (Phospholipid) into inhibitor (lysophospholipid), constant quantities of preinhibitor were added to plasma and kidney homogenate. Addition of preinhibitor to plasma did not modify the quantity of Angiotensin I that developed. On the other hand, addition of preinhibitor to crude kidney homogenate, followed by incubation with human angiotensinogen, caused a significant fall in the quantity of Angiotensin I generated. While plasma is deficient in the specific enzyme delegated to the transformation of preinhibitor into inhibitor, it appears that this enzyme is present in the kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852632
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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