ISSN:
1432-198X
Keywords:
Key words: Haemolytic uraemic syndrome
;
Neutrophil
;
Oxidative burst
;
Elastase
;
Chemiluminescence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract . Neutrophil-mediated tissue damage has been implicated in the pathogenesis of diarrhoea-associated haemolytic uraemic syndrome (D+ HUS). This study evaluates priming and activation of the neutrophil oxidative burst in D+ HUS using chemiluminescent techniques. Peripheral blood neutrophils from 11 children with acute D+ HUS were examined. No difference was found in the oxidative burst of neutrophils from patients and controls. Serum elastase levels were measured in 8 patients and found to be significantly elevated. Although elastase results suggest neutrophil activation, chemiluminescence studies do not confirm this in the peripheral blood neutrophil. This does not support a significant role for circulating agents in priming and activating the peripheral blood neutrophil.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004670050136
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