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  • 1
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopie der HĂ€mangioblastome des ZNS und der angioblastischen Meningiome (1971)
    Springer
    Acta neuropathologica 19 (1971), S. 184-207 
    Details
    ISSN: 1432-0533
    Keywords: Haemangioblastoma of the Brain ; Angioblastic Meningioma ; Blastomatous Vessels ; “Zwischenzellen” ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 4 hemangioblastomas of the cerebellum, 1 of the choroid plexus, 1 of the spinal cord, and 3 angioblastic meningiomas of the brain were investigated with the electron microscope. They all show a similar histological arrangement of vessels, intervascular cells (Zwischenzellen), and the intercellular space. The vessels of the tumors regardless where they originate from are identical in their appearance. They differ from autochthonous vessels by the irregular form of the endothelium and the presence of pores. The “Zwischenzellen” of hemangioblastomas are not so uniform as those of angioblastic meningiomas. Corresponding to differences in the nucleus/cytoplasma ratio, the development of the ER and the number of cytofilaments as well as the content of lipid droplets hemangioblastomas can be subdivided in 4 types. Nevertheless they constitute a cytological unity. In 3 hemangioblastomas mast cells were found. glial cells mixed up with tumor cells are present only in the border of tumorous and nervous tissue. The extracellular space is filled either with a protein-rich exsudate or with collagen fibrils. — The electron microscopic findings support the histological identity of hemangioblastomas and angioblastic meningiomas. The relation of “Zwischenzellen” to the vessel walls, their similarity to endothelial cells, and their tendence to form basement membranes indicate that they derive from blastomatous vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684596
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  • 2
    Electronic Resource
    Electronic Resource
    An electron microscopic study of meningiomas (1969)
    Springer
    Acta neuropathologica 13 (1969), S. 301-323 
    Details
    ISSN: 1432-0533
    Keywords: Meningiomas ; Electron Microscopy ; Endotheliomatous, Fibromatous Type ; Light Cells ; Dark Cells ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 17 chirurgisch entfernte Meningiome vom endotheliomatösen und 5 vom fibromatösen Typ wurden elektronenmikroskopisch untersucht. Unterschiede im Entwicklungsgrad der cytoplasmatischen FortsĂ€tze und der Beziehungen zwischen den Plasmamembranen der Tumorzellen wurden in den endotheliomatösen Meningeomen beobachtet. In 4 fibromatösen Tumoren sind die zelligen Areale von bindegewebigen RĂ€umen umgeben. Auch wenn die meisten Tumorzellen helle Zellen sind und sich nicht wesentlich von den Tumorzellen der endotheliomatösen Meningiome unterscheiden, ist die histologische Anordnung der fibromatösen klar von derjenigen der endotheliomatösen Meningeome zu trennen. Ausschlaggebend dafĂŒr ist die starke Entwicklung des Bindegewebes. Die Dunkelzellen lassen sich in zwei Typen gliedern: Typ I wird in vier Tumoren mit stark ausgebildetem Bindegewebe angetroffen. Die Analyse der inneren Zellstruktur sowie das Vorliegen von ÜbergĂ€ngen zwischen hellen und dunklen Zellen machen es wahrscheinlich, daß diese nur verschiedene Typen einer einzigen Ursprungszelle darstellen. Die Bedeutung dieser verschiedenen Erscheinungsformen der Meningiomzellen wird diskutiert. Die Ultrastruktur der Tumorzellen Ă€hnelt derjenigen der normalen arachnoidalen Zellen. RĂŒckschlĂŒsse auf die blastodermale Herkunft der normalen und tumoralen meninigalen Zellen auf Grund ihrer ultrastrukturellen Merkmale erscheinen verfrĂŒht.
    Notes: Summary Seventeen surgically removed meningiomas of the endotheliomatous and five of the fibromatous type were investigated with an electron microscope. Differences of the development of cytoplasmic processes and the relations between plasma membranes of blastomatous cells were observed in endotheliomatous meningiomas. In four of the fibromatous tumors the cell groups were surrounded by spaces of connective tissue. Although most of the tumor cells were light cells and are not essentially different from the tumor cells of the endotheliomatous meningiomas, the histological structure of fibromatous meningiomas is clearly distinguished from the endotheliomatous type, because of the greater amount of connective tissue. The dark cells may be divided into two types: the first was found in those four tumors, where the connective tissue is well developed, while the second one only occurred in one of the tumors. The analysis of the inner cell structure as well as the presence of interstages between dark and light cells makes it probable that dark and light cells are different types of one original cell. The cause of this different appearance of the menigioma cells is discussed. The fine structure of the tumor cells showed a great similarity with that of normal arachnoidal cells. Conclusions on the blastodermic origin of normal and blastomatous meningial cells on the basis of ultrastructural characteristics, however, seem to be premature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686120
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  • 3
    Electronic Resource
    Electronic Resource
    The ultrastructure of medulloblastomas (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 271-284 
    Details
    ISSN: 1432-0533
    Keywords: Medulloblastoma ; Electron Microscopy ; Arachnoid Sarcoma ; Lymphocyte-Like Cells ; Dark Cells ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 9 Medulloblastome wurden elektronenmikroskopisch untersucht. Sie zeigten eine relativ einheitliche histologische und cytologische Struktur. Die Tumorzellen haben eine wechselnde Form, wenig Organellen und in der Regel zahlreiche cytoplasmatische FortsĂ€tze. In Gewebspartikeln, die nach der vorherigen lichtmikroskopischen Untersuchung aus dem Tumorzentrum stammten, wurden keine Zellen mit glialer oder neuronaler Differenzierung beobachtet. Nur in den am Tumorrand gelegenen Infiltrationszonen, wo die Tumorgrenze nicht mehr sicher zu bestimmen war, fanden sich gliale oder neuronale Zellelemente. — Das Medulloblastom hat die wesentlichen morphologischen Kriterien der kleinzelligen Sarkome und des embryonalen Gewebes. Deren gemeinsames Charakteristicum, daß sie nĂ€mlich keine speziellen Differenzierungen besitzen, ist auch eine spezifische Eigenschaft des Medulloblastoms.
    Notes: Summary 9 medulloblastomas were investigated by electron microscopy. They all showed a rather unique histological and cytological structure. The cells were differently shaped, had in general many cytoplasmic processes and only few organells. Special differentiations which would have made tumour elements look like glial or neural cells were not observed when the tissue samples under investigation were carefully selected by light microscopical examination. Glial or neural elements were found only in infiltration zones where no clear distinction between pre-existing cerebellar and tumourous tissues could be made by conventional histological investigation. Medulloblastomas have essentially the same appearance as parvicellular sarcomas or embryonic tissues. Their common characteristic, viz. that they usually show no special differentiation, is also the most specific quality of medulloblastomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686892
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  • 4
    Electronic Resource
    Electronic Resource
    Klinische und ultrastrukturelle Befunde bei einer juvenilen Form der amaurotischen Idiotie mit protrahiertem Verlauf (1973)
    Springer
    European archives of psychiatry and clinical neuroscience 218 (1973), S. 79-91 
    Details
    ISSN: 1433-8491
    Keywords: Storage Disease ; Juvenile Amaurotic Idiocy ; Curvilinear Bodies ; Electron Microscopy ; Rectal Biopsy ; Speicherkrankheit ; Juvenile amaurotische Idiotie ; CurvilineÀre Körper ; Elektronenmikroskopie ; Rectum Biopsie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem Fall von juveniler amaurotischer Idiotie mit protrahiertem Verlauf (Beginn der Erkrankung mit 14 Jahren, Alter des Patienten 52 Jahre) wird ĂŒber die Ultrastruktur des Speichermaterials in einer Rectumbiopsie berichtet. Das in Makrophagen der Mucosa gespeicherte Material entspricht den fĂŒr die juvenile Form charakteristischen curvilineĂ€ren Strukturen. GegenĂŒber der Kufsschen Form lĂ€ĂŸt sich der Fall ultrastrukturell durch das Fehlen der bei der SpĂ€tform beschriebenen Lipofuscin-Granula abgrenzen. Das klinische Bild spricht auch fĂŒr die juvenile Form. Auffallend waren neben dem protrahierten Verlauf der verzögerte Beginn der Erkrankung sowie das spĂ€te Einsetzen der geistigen Retardierung.
    Notes: Summary The ultrastructure of storage material in a rectal biopsy taken from a patient with juvenile amaurotic idiocy with protracted course (onset of illness: 14 years; age of patient: 52 years) is described. The material stored in macrophages of the mucosa was like the curvilinear structures characteristic of the juvenile type. It was possible to exclude Kufs' type in this case by absence of the lipofuscin granula seen in the fine structures in the adult type. The clinical picture was also consistent with the juvenile form. Apart from the protracted course, other striking features were the delayed onset of the disease and the late beginning of mental retardation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347090
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