ISSN:
1432-0878
Keywords:
6-hydroxydopamine
;
Noradrenaline
;
Extraneuronal uptake
;
Adrenal cortex
;
Falck-Hillarp technique
;
Electron microscopy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary 6-hydroxydopamine (6-OHDA) was shown to cause ultrastructural changes in adrenocortical cells of lizards and rats. These changes comprised the formation of dense bodies with lamellar and crystalloid patterns, a decrease in the number of mitochondria and structural alterations of mitochondria. Alterations in adrenocortical cells of lizards and rats differed in both qualitative and quantitative aspects. Adrenomedullary cells were not affected as a rule. Only in young animals did 6-OHDA cause deposits of an electrondense material in medullary cells. An attempt was made to obtain information on amine uptake into cortical cells using the Falck-Hillarp technique to analyse the in-vivo and in-vitro uptake of noradrenaline (NA) into the adrenal cortex in adult rats. Extraneuronal uptake into heart and spleen was studied as well. Our results suggest that NA is taken up into cortical cells, particularly into nuclei, after exposure to 10-4 gm/ml in-vitro indicating that uptake of 6-OHDA is also likely. Investigations using labelled 6-OHDA are required for further elucidating its extraneuronal uptake.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00219265
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