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  • Nasal mucosa  (3)
  • Engineering  (2)
  • Neuropeptide Y  (2)
  • Electropolymerization  (1)
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Years
Keywords
  • 1
    ISSN: 0167-0115
    Keywords: Conformational entropy ; Ligand-receptor interaction ; Molecular dynamics ; Molecular modeling ; Neuropeptide Y ; Pig spleen
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0167-0115
    Keywords: Nasal mucosa ; Neuropeptide Y ; Noradrenaline ; Peptide histidine isoleucine ; Pig ; Somatostatin ; Vascular control ; Vasoactive Intestinal Polypeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0878
    Keywords: Nasal mucosa ; Neuropeptide Y (NPY) ; Vasoactive intestinal polypeptide (VIP) ; Peptide histidine isoleucine (PHI) ; Noradrenaline ; Sympathetic/parasympathetic innervation ; Pig ; Cat ; Guinea-pig ; Rat ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The occurrence of neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine (PHI) in the sympathetic and parasympathetic innervation of the nasal mucosa was studied in various species including man. A dense network of NPY-immunoreactive (IR) fibres was present around arteries and arterioles in the nasal mucosa of all species studied. NPY was also located in nerves around seromucous glands in pig and guinea-pig, but not in rat, cat and man. The NPY-IR glandular innervation corresponded to about 20% of the NPY content of the nasal mucosa as revealed by remaining NPY content determined by radioimmunoassay after sympathectomy. These periglandular NPY-positive fibres had a distribution similar to the VIP-IR and PHI-IR nerves but not to the noradrenergic markers tyrosine hydroxylase (TH) or dopamine-β-hydroxylase (DBH). The NPY nerves around glands and some perivascular fibres were not influenced by sympathectomy and probably originated in the sphenopalatine ganglion where NPY-IR and VIP-IR ganglion cells were present. The venous sinusoids were innervated by NPY-positive fibres in all species except the cat. Dense NPY and DBH-positive innervation was seen around thick-walled vessels in the pig nasal mucosa; the latter may represent arterio-venous shunts. Double-labelling experiments using TH and DBH, and surgical sympathectomy revealed that the majority of NPY-IR fibres around blood vessels were probably noradrenergic. The NPY-positive perivascular nerves that remained after sympathectomy in the pig nasal mucosa also contained VIP/PHI-IR. The major nasal blood vessels, i.e. sphenopalatine artery and vein, were also densely innervated by NPY-IR fibres of sympathetic origin. Perivascular VIP-IR fibres were present around small arteries, arterioles, venous sinusoids and arterio-venous shunt vessels of the nasal mucosa whereas major nasal vessels received only single VIP-positive nerves. The trigeminal ganglion of the species studied contained only single TH-IR or VIP-IR but no NPY-positive ganglion cells. It is concluded that NPY in the nasal mucosa is mainly present in perivascular nerves of sympathetic origin. In some species, such as pig, glandular and perivascular parasympathetic nerves, probably of VIP/PHI nature, also contain NPY.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 298-303 
    ISSN: 1434-4726
    Keywords: Nasal mucosa ; Adrenergic mechanisms ; β2-agonist ; β3agonist ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In thiopentone-anesthetized mature pigs (n = 7), local intra-arterial infusion of the β2-adrenoceptor agonists terbutaline and salbutamol and the β3-agonist BRL 37344 induced dose-dependent increases in nasal arterial blood flow (BF) and volume of the nasal mucosa (reflecting capacitance vessel function). Increases were also found in the laser Doppler flowmeter signal, reflecting superficial mucosal BE. In contrast to terbutaline and salbutamol, BRL 37344 showed marked effects on volume. Pretreatment with the β-adrenoceptor blocker propranolol significantly reduced the vasodilatory effects of terbutaline and salbutamol, whereas the BF increase evoked by BRL 37344 was not affected. Exogenous noradrenaline (NA) induced in vitro dose-dependent contractions of human nasal mucosa biopsies obtained from patients with non-allergic chronic rhinitis (n = 21) or non-allergic nasal polyposis (NANP, n = 16). On a molar basis, the contractile effect of NA was significantly greater in nasal mucosa samples without histological abnormalities when compared to biopsies with abundant inflammatory cells and edema within the submucosa. In the presence of propranolol, the vasoconstrictor effect of NA was significantly enhanced in biopsies with abundant inflammatory cells obtained from patients with NANP (P〈0.01). This observation suggests the possible occurrence of a β2 hyper-reactivity in the nasal mucosa of patients with NANP. After precontraction in a Krebs-Ringer solution with 50 nM K+, all nasal biopsies studied showed dose-dependent relaxation to terbutaline, salbutamol and BRL 37344. This relaxant effect was markedly reduced after pretreatment with propranolol. These observations suggest that β2- and β3-adrenergic vasodilatatory mechanisms may be similar in the nasal mucosa of the pig and man.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1572-9001
    Keywords: Electropolymerization ; frontier orbital modeling ; poly(dialkoxybenzene)s ; conductive polymers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A modeling strategy, based on (i) quantum semiempirical calculation of the electronic structure of the successive intermediate oligomers and (ii) evaluation of the activation energy of the successive coupling reactions by use of the frontier orbital model, has been used to study the growth of a wide set of conductive polymers and is illustrated with poly(1,2-dialkoxybenzene) and poly(1,4-dialkoxybenzene) generated by electrochemical oxidation of the corresponding monomer. These monomers have been chosen because they are known to yield polymers of completely different structures. The strategy, which is designed to be as little computer time-consuming as possible, allows us to predict a growth trend in agreement with the structure inferred from spectrochemical experiments. In the case of poly(1,2-dialkoxybenzene) it suggests the formation of a cyclic tetramer as a byproduct detected in small quantities by means of MALDI spectroscopy. This modeling strategy allows one to describe the electronic modifications induced by the growth of a highly conjugated structure. It suggests that oxidation of the successive oligomers at high doping level and quinonic deformation are key factors for the growth of long and regular polymer structures
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 13 (1997), S. 139-149 
    ISSN: 1069-8299
    Keywords: parametric optimization ; finite difference method ; gradient method ; composite structures ; sport equipment ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper describes the implementation of a parametric optimization process in the field of composite structure design. The application concerns alpine skis. Using a reference ski, the process enables the calculation of the optimum shapes for a complete range of skis and checks their behaviour on snow. The objective function is formulated as a least-squares problem involving nine static bending flexibilities of the ski, considered as a simply-supported beam on nine predetermined spans. The composite cross-section properties and the longitudinal profile of the structure are taken into account in a parametric geometry approach. After the homogenization process, integration of the bending equation is carried out using a finite difference approach. The line search procedure uses the gradient method and the descent parameter optimization is carried out using an adapted linear approximation. The discussion of the results highlights the satisfying compromise between precision and calculation time. The procedure constitutes an original implementation of numerical methods in the area of sports equipment. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 11 (1987), S. 381-390 
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Hydraulic and mechanical properties of rock masses are largely dependent upon the distribution and variation of fracture areas. Consequently, it is essential to develop good models for analysing the spatial geometric characteristics of fracture fields. The latter, however, may be ascertained only by measuring open cuts or boreholes. The most important factor from the analysis of areas is to be able to determine spatial networks. Without an exhaustive and expensive inventory, the classical methods involving measurements of dip and strike do not provide either a correct estimation of fracture orientations in space, or a good estimation of their distribution.At present, automatic analysis of linear traces on large plane areas is used by several authors1,2 and the field strike and dip measurements are applied only for verification purposes. This method of computing spatial networks is especially suitable because of the nature of data so obtained, since it permits various simulations on computed networks. It is based upon classical methods of vector geometry that involve a measurements data matrix and provide a means of solving a double system of equations. Results are the directional spatial fracture densities. The object of this paper is to define the geometric parameters of this problem and the computation method, to present an example and, finally, to conclude with critical comments supported by certain proposals for a variety of applications.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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