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  • 1
    Electronic Resource
    Electronic Resource
    In vivo radioprotective effect of AcSDKP on canine myelopoiesis (1997)
    Springer
    Annals of hematology 74 (1997), S. 117-122 
    Details
    ISSN: 1432-0584
    Keywords: Key words AcSDKP ; Hematopoietic stem cells ; Radioprotection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The tetrapeptide acetyl-N–Ser-Asp-Lys-Pro (AcSDKP) interferes with G1/S-phase progression, and the resulting cell cycle arrest is thought to protect hematopoietic stem cells against injury by cycle-active cytotoxic agents. We investigated the radioprotective effect of AcSDKP in a canine radiation model. Dogs were given total-body irradiation (TBI) at an exposure rate of 10 cGy/min, either without further therapy (control) or with administration of AcSDKP at 0.05–500 μg/kg/24 h beginning before and continuing until after completion of TBI. At 400 cGy of TBI, one of 28 control dogs and one of eight AcSDKP-treated dogs recovered hematopoiesis (p=0.40). At 300 cGy, seven of 21 control dogs recovered hematopoiesis compared with five of five AcSDKP-treated dogs (p=0.01). In dogs given 300 cGy and AcSDKP, the granulocyte nadirs were less profound (p=0.04) and occurred later (p=0.04) than among controls; platelet kinetics did not differ. These data suggest, therefore, that AcSDKP provides a radioprotective effect in dogs exposed to 300 cGy TBI. Such an effect might be beneficial in recipients of intensive radiation therapy. Conceivably, the effect on hematopoietic recovery could be amplified by growth factor administration after irradiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050268
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    246. Knochenheilung im elektromagnetischen Wechselfeld? Rechts-Links-Versuch an infizierten Pseudarthrosen (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 709-710 
    Details
    ISSN: 1435-2451
    Keywords: Electrotherapy ; Bone, non-union ; Osteomyelitis ; Bone graft ; Elektrotherapie ; Pseudarthrose ; Osteomyelitis ; Spongiosaplastik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Atrophe, infizierte Defektpseudarthrosen beiderUlnae von 21 altenBeagle-Weibchen wurden im Rechts-Links-Versuch mit elektromagnetischen Wechselfeldern in Verbindung mit Wechselstromübertragern am Knochen nach Kraus behandelt. Ausgewertet wurden Röntgenbilder, Microan-giographien, Mikroradiographien, polychrome Sequenzmarkierung, gefärbte Schnitte und Polarisation. Auf der behandelten Seite ergab sich bei einer Gruppe lediglich vermehrte periostale Reaktion, bei einer 2. Gruppe mit Spongiosaplastik dagegen vermehrte Knochenneubildung and besserer Durchbau der Pseudarthrosen.
    Notes: Summary Atrophic and infected non-unions of both ulnae in 21 female beagle dogs were treated with alternating electromagnetic fields and AC-transducers at the bone according to the method of Kraus in a right-left trial. X-rays, microangiography, microradiography, polychrome sequence labeling, stained histology, and polarization are evaluated. One group showed more periosteal reaction on the treated side but no better healing. The second group with additional cancellous bone graft developed more new bone in the defect on the electrically treated side compared with the control side.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579536
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    Paper (German National Licenses)
    Fulltext
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