ISSN:
1612-1112
Keywords:
Open-tubular liquid chromatography
;
Capillary electrochromatography and electrophoresis
;
Cellulose derivatives
;
Chiral stationary phase (CSP)
;
Enantiomer separation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The feasibility of enantiomer separations by normal-phase and reversed-phase open-tubular liquid chromatography as well as by capillary electrochromatography in 50 μm i.d. fused silica capillaries coated with cellulose derivatives is demonstrated for a number of chiral pharmaceuticals. The excellent enantioselectivity of 3,5-dimethylphenylcarbamoyl cellulose andpara-methylbenzoyl cellulose has been transferred from HPLC to a miniaturized, open-tubular system. A comparison of HPLC, OTLC and CEC is made and the influence of retention and temperature on efficiency, selectivity and resolution is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02290286
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