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  • 1
    Electronic Resource
    Electronic Resource
    Localization of the CD15-epitope in the inner ear of the developing mouse (1996)
    Springer
    Cell & tissue research 283 (1996), S. 395-401 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Cochlear duct ; Vestibular organ ; Tectorial membrane ; Organ of Corti ; Endolymphatic sac ; 3-Fucosyl-N-acetyl-lactosamine (CD15) ; Glycoconjugates ; Mouse (MNRI)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The expression of the 3-fucosyl-N-acetyl-lac-tosamine (CD15) epitope during the embryonic development of the mouse inner ear has been immunohistochemically studied on paraffin sections from day 8.5 to day 19 of gestation. Consecutive steps of morphological development are accompanied by up- and down-regulation of CD15 expression and changing cell patterns. Expression levels are reduced once structural maturation has been accomplished. Since CD15 has been described as a determinant that is expressed during critical developmental steps, it is speculated that the changes in the epitope expression in the inner ear reflect relevant stages of differentiation. This system may thus serve as a model for understanding inner ear development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050550
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Time-dependent alterations of 3-fucosyl-N-acetyl-lactosamine (CD15) expression in the endolymphatic sac of adult guinea pigs after glycerol administration (1996)
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 136-141 
    Details
    ISSN: 1434-4726
    Keywords: Endolymphatic sac ; Glycoconjugates ; Fluid regulation ; Immune response ; Menière's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study examined the effect of glycerol administration on 3-fucosyl-N-acetyl-lactosamine (CD15) epitope expression in the endolymphatic sac (ES) of the guinea pig's inner ear. Adult guinea pigs were injected intravenously with glycerol (2 g/kg body wt.). CD15 expression was studied at 80 min up to 5 h after treatment. In untreated animals single cells and cell groups in the ES expressing CD15 epitope intra- and intercellularly were identified by immunohistochemistry to be mainly in the epithelial layer of the rugosal and distal part of the sac. Glycerol administration modulated the expression of CD15 epitope. In the epithelial layer, expression decreased and was nearly depleted after 3 h. After 4 h of glycerol administration, CD15 expression reappeared and reached the comparable level of controls. The numbers of CD15-positive cells in the lumen of the ES increased steadily and arrived at their the highest levels in 2-h specimens. The localization of CD15-epitope expression and its modulation after glycerol administration within the ES implies that this molecule may play a role in re-establishing the sac's normal function. In addition, we speculate that CD15 may be associated with processes of an immune response in the inner ear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00615110
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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