ISSN:
1573-7225
Keywords:
Endometrial cancer
;
DDT
;
PCB
;
organochlorines
;
United States
;
women
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objectives: Endogenous and exogenous estrogens are important in the development of endometrial cancer. Several organochlorine compounds, such as o,p′-DDT, have estrogenic properties. The objective of this case-control analysis was to examine serum concentrations of organochlorine compounds and risk of endometrial cancer. Methods: Analyses were based on a sample of 90 endometrial cancer cases and 90 individually matched community controls from a multicenter case-control study in five geographic regions of the United States. Information on potential confounders, including menstrual and reproductive factors, cigarette smoking, diet, and weight, was obtained by interview. Results: The adjusted relative risk of endometrial cancer in the highest quartile of exposure compared with women in the lowest quartile was 0.7 (95 percent confidence interval [CI] = 0.2-2.0) for p,p′-DDE, and 0.9 for total polychlorinated biphenyls (PCBs) (CI = 0.4-2.5). Conclusions: These findings do not support the hypothesis that organochlorine compounds are linked to the development of endometrial cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008823802393
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