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  • Neuropeptide Y  (2)
  • Endopeptidase inhibition  (1)
  • Engineering General  (1)
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  • 1
    ISSN: 0167-0115
    Keywords: Conformational entropy ; Ligand-receptor interaction ; Molecular dynamics ; Molecular modeling ; Neuropeptide Y ; Pig spleen
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0167-0115
    Keywords: Nasal mucosa ; Neuropeptide Y ; Noradrenaline ; Peptide histidine isoleucine ; Pig ; Somatostatin ; Vascular control ; Vasoactive Intestinal Polypeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 83-85 
    ISSN: 1434-4726
    Keywords: Human nasal mucosa ; Sensory neuropeptides ; Endopeptidase inhibition ; Phosphoramidon ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The functional effects of the intranasal application of exogenous vasoactive intestinal polypeptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) were evaluated in 12 healthy volunteers before and after neutral endopeptidase (NEP) inhibition with phosphoramidon (PA) and angiotensin-converting enzyme (ACE) inhibition with captopril. The three neuropeptides increased nasal airway resistance (NAR) measured by anterior rhinomanometry and superficial capillary blood flow measured by laser Doppler flowmetry (LDF). After pretreatment of the nasal mucosa with PA, the effects of VIP, SP and CGRP on the LDF signal, NAR and mucus production were potentiated, whereas local pretreatment with captopril did not modify these functional effects. These observations suggest that NEP, but not ACE, may participate in the catabolism of neuropeptides when applied directly to the human nasal mucosa. Furthermore, since these neuropeptides induced nasal obstruction, increased blood flow and rhinorrhea, a decreased activity of the enzymes involved in their degradation could be involved in the physiopathology of rhinitis symptoms.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 11 (1987), S. 381-390 
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Hydraulic and mechanical properties of rock masses are largely dependent upon the distribution and variation of fracture areas. Consequently, it is essential to develop good models for analysing the spatial geometric characteristics of fracture fields. The latter, however, may be ascertained only by measuring open cuts or boreholes. The most important factor from the analysis of areas is to be able to determine spatial networks. Without an exhaustive and expensive inventory, the classical methods involving measurements of dip and strike do not provide either a correct estimation of fracture orientations in space, or a good estimation of their distribution.At present, automatic analysis of linear traces on large plane areas is used by several authors1,2 and the field strike and dip measurements are applied only for verification purposes. This method of computing spatial networks is especially suitable because of the nature of data so obtained, since it permits various simulations on computed networks. It is based upon classical methods of vector geometry that involve a measurements data matrix and provide a means of solving a double system of equations. Results are the directional spatial fracture densities. The object of this paper is to define the geometric parameters of this problem and the computation method, to present an example and, finally, to conclude with critical comments supported by certain proposals for a variety of applications.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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