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  • 1
    Electronic Resource
    Electronic Resource
    Distribution and functional significance of the endothelin receptor subtypes in the rat adrenal gland (1997)
    Springer
    Cell & tissue research 288 (1997), S. 345-352 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Endothelins ; Endothelin receptors ; Adrenal gland ; Steroid secretion ; Catecholamine secretion ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named ETA and ETB. ET-1 binds to both ETA and ETB, whereas the isopeptide ET-3 preferentially binds to ETB. The localization of ETA and ETB receptors in the rat adrenal gland and their involvement in the adrenal secretagogue effect of ETs has been studied in vitro. Autoradiographic assessment of the selective displacement of [125I]ET-1, [125I]ET-3 and [125I]BQ-3020 (an ETB agonist) by BQ-123 or BQ-788 (specific antagonists of ETA and ETB, respectively) indicates that the zona glomerulosa and adrenal medulla possess both ETA and ETB, whereas the zona fasciculata/reticularis is exclusively provided with ETB. ET-1, ET-3 and BQ-3020 enhance aldosterone and corticosterone secretion by dispersed cells of the zona glomerulosa and zona fasciculata/reticularis, respectively. BQ-123 does not affect the secretagogue action of these three agonists, whereas BQ-788 completely annuls it. ET-1 induces a marked rise in catecholamine release by fragments of the adrenal medulla, and both BQ-123 and BQ-788 partially reverse this effect. ET-3 and BQ-3020 elicit a catecholamine release that is less intense than that produced by ET-1; this response is unaffected by BQ-123 and abolished by BQ-788. Thus, in the rat, the corticosteroid secretagogue effect of ETs seems to be exclusively mediated by the ETB receptor subtype, and the catecholamine secretagogue action by both ETA and ETB. The functional relevance of ETA receptors present in the zona glomerulosa remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050820
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanismus der thermischen Isomerisierung von Thiophosphorsäure-O-2-butenylester-O,O-dimethylester. Kinetische Untersuchung (1978)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 111 (1978), S. 56-64 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Mechanism of the Thermal Isomerisation of O-2-Butenyl O,O-Dimethyl Thiophosphate. Kinetic StudyThe thermal isomerisation of O-2-butenyl O,O-dimethyl thiophosphate (1b) (scheme 3) obeys first order rate law. Solvent polarity does not affect the parameters of activation, but influences a little the rate constants. The kinetic data and the observed “special” salt effect lead to the conclusion that the isomerisation proceeds by a dissociative mechanism. Ion pairs as intermediates are proposed.
    Notes: Die thermische Isomerisierung von Thiophosphorsäure-O-2-butenylester-O,O-dimethylester (1b) (Schema 3) verläuft nach einem Geschwindigkeitsgesetz 1. Ordnung. Die Polarität des Mediums beeinflußt nicht die Aktivierungsparameter und übt lediglich einen minimalen Einfluß auf die Geschwindigkeitskonstanten aus. Die kinetischen Daten und der festgestellte „spezielle“ Salzeffekt lassen den Schluß zu, daß diese Isomerisierung einem intramolekularen ionischen Mechanismus folgt. Als ionische Zwischenstufe werden Ionenpaare postuliert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19781110105
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Kinetik der Pistschimuka-Reaktion (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 2465-2468 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Kinetics of the Pistschimuka ReactionReactions of O,O,O-triethyl phosphoroselenoate and O,O,O-triethyl phosphorothioate with methyl iodide in N-methylacetamide were found to be of second order. The rate constants and the activation parameters are given.
    Notes: Selenophosphorsäure-O,O,O-triäthylester und Thiophosphorsäure-O,O,O-triäthylester reagieren mit Methyljodid in N-Methylacetamid nach einem Geschwindigkeitsgesetz 2. ordnung. Geschwindigkeitskonstanten und Aktivierungsparameter sind angegeben.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751080733
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  • 4
    Electronic Resource
    Electronic Resource
    Selektive Alkylierung von mehrbasigen Säuren des 4-bindigen Phosphors mit Trialkylphosphit (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 2589-2592 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Selective Alkylation of Polybasic Phosphoric Acids with Trialkyl PhosphiteThe synthesis of mono-, di-, and triethyl phosphate (1-3) as well as of mono- and diethyl phenylmethane phosphonate (4, 5) by selective alkylation of orthophosphoric and phenylmethane phosphonic acid with triethyl phosphite is described.
    Notes: Die Synthese von Phosphorsäure-monoäthylester, -diäthylester und -triäthylester (1-3) sowie von Phenylmethanphosphonsäure-monoäthylester und -diäthylester (4, 5) durch selektive Alkylierung der Orthophosphorsäure und Phenylmethanphosphonsäure mit Triäthylphosphit wird beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751080813
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