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  • 1
    Digitale Medien
    Digitale Medien
    Distribution and functional significance of the endothelin receptor subtypes in the rat adrenal gland (1997)
    Springer
    Cell & tissue research 288 (1997), S. 345-352 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Key words: Endothelins ; Endothelin receptors ; Adrenal gland ; Steroid secretion ; Catecholamine secretion ; Rat (Wistar)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract. Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named ETA and ETB. ET-1 binds to both ETA and ETB, whereas the isopeptide ET-3 preferentially binds to ETB. The localization of ETA and ETB receptors in the rat adrenal gland and their involvement in the adrenal secretagogue effect of ETs has been studied in vitro. Autoradiographic assessment of the selective displacement of [125I]ET-1, [125I]ET-3 and [125I]BQ-3020 (an ETB agonist) by BQ-123 or BQ-788 (specific antagonists of ETA and ETB, respectively) indicates that the zona glomerulosa and adrenal medulla possess both ETA and ETB, whereas the zona fasciculata/reticularis is exclusively provided with ETB. ET-1, ET-3 and BQ-3020 enhance aldosterone and corticosterone secretion by dispersed cells of the zona glomerulosa and zona fasciculata/reticularis, respectively. BQ-123 does not affect the secretagogue action of these three agonists, whereas BQ-788 completely annuls it. ET-1 induces a marked rise in catecholamine release by fragments of the adrenal medulla, and both BQ-123 and BQ-788 partially reverse this effect. ET-3 and BQ-3020 elicit a catecholamine release that is less intense than that produced by ET-1; this response is unaffected by BQ-123 and abolished by BQ-788. Thus, in the rat, the corticosteroid secretagogue effect of ETs seems to be exclusively mediated by the ETB receptor subtype, and the catecholamine secretagogue action by both ETA and ETB. The functional relevance of ETA receptors present in the zona glomerulosa remains to be investigated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004410050820
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  • 2
    Digitale Medien
    Digitale Medien
    Synthese des Thiophosphatidylcholins und seiner Analogen (1991)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1991 (1991), S. 833-834 
    Details
    ISSN: 0170-2041
    Schlagwort(e): Thiophosphatidylcholine, analogoues of ; 1,3,2-Dioxaphospholane, 2-(2,3-diacyloxypropylthio-), rearrangment of ; Thiophospholipids ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Synthesis of Thiophophatidylcholine and Its AnaloguesSynthesis of thiophatidylcholine 5, its phosphonothionate 7 and phosphonate 9 analogues are described. A novel facile rearrangement of 2-(2,3-distearoyloxypropylthio)-1,3,2-dioxaphospholane (3) into 2-(2,3-distearoyloxypropyl)-1,3,2-dioxaphospholane 2-sulfide (6) was observed by 13P-NMR spectroscopy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.1991199101142
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  • 3
    Digitale Medien
    Digitale Medien
    Neue Synthesewege zu Thiophosphatidylcholin mit C—S—P-Bindung (1990)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1990 (1990), S. 923-925 
    Details
    ISSN: 0170-2041
    Schlagwort(e): 1-Propanethiol, 2,3-diacyloxy derivatives of ; Thiophospholipids ; Thiophosphatidylcholine ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: New Synthetic Routes to Thiophosphatidylcholine with C — S — P BondA simple and effective synthesis of thiophosphatidylcholine (4) based on phosphorylation of 2,3-di(stearoyloxy)-1-propa-nethiol (1a) or 2,3-di(stearoyloxy)-1-(trimethylsilyl)-1-propane-thiol (1b) with 2-chloro-2-oxo-1,3,2-dioxaphospholane (2) followed by ring opening of the resultant product 3 is described.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.1990199001169
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  • 4
    Digitale Medien
    Digitale Medien
    Etheranaloge der Thio- und Dithiophospholipide mit C—S—P-Bindung (1993)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1993 (1993), S. 1327-1329 
    Details
    ISSN: 0170-2041
    Schlagwort(e): Thiophospholipids ; Thioglycerol ; Dithioglycerol ; Phospholipids ; Lipids ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Ether Analogues of Thio- and Dithiophospholipids with C-S-P BondThe efficient synthesis of 1-O-hexadecyl-2-O-methyl-3-thioglycero-3-phosphocholine (5a) and 1-S-hexadecyl-2-O-methyl-1,3-dithioglycero-3-phosphocholine (5b) based on phosphorylation of 1-O-hexadecyl-2-O-methyl-3-thioglycerol (3a) and 1-S-hexadecyl-2-O-methyl-1,3-dithioglycerol (3b) with 2-chloro-2-oxo-1,3,2-dioxaphospholane (6) followed by ring opening of the resulting intermediates 4a and 4b is described.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.1993199301216
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