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  • Engineering General  (3)
  • Neuropathy  (2)
  • culture media  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Neurotoxicology of vincristine in the cat (1983)
    Springer
    Archives of toxicology 52 (1983), S. 83-90 
    Details
    ISSN: 1432-0738
    Keywords: Vincristine ; Neuropathy ; Giant axon ; Paranodal demyelination ; Wallerian degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vincristine is a vinca alkaloid widely utilized in cancer chemotherapy. Its major clinical limitation is due to a drug induced sensory-motor neuropathy, the pathogenesis of which is poorly understood. This communication describes the morphological basis of a Vincristine neuropathy in cats. Major pathological lesions were focal axonal swellings (giant axon formations) due to malaligned accumulations of neurofilaments and secondary demyelination of the paranodal type. These were primarily confined to the proximal portions of the peripheral nerves. The distal portions of the peripheral nerves contained only a few giant axon formations. Wallerian degeneration was noted to involve a small number of nerve fibers in the distal regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00354768
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  • 2
    Electronic Resource
    Electronic Resource
    Neurotoxicology of vincristine in the cat (1981)
    Springer
    Archives of toxicology 48 (1981), S. 253-264 
    Details
    ISSN: 1432-0738
    Keywords: Vincristine ; Neuropathy ; Spindles ; Conduction velocities ; Spinal reflexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cats were given vincristine sulfate (50 μg/kg i.v. every 4 days) and studied after 7–29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or other proprioceptors which responded to muscle stretch were encountered. Those primary endings of soleus muscle spindles which did respond were significantly reduced in dynamic but not length sensitivity. Length sensitivity of secondary endings was unchanged. Thresholds of secondary but not primary endings were elevated. The average conduction velocity of soleus motor axons was reduced 30% but no deficit was detected in motor nerve terminal function. Indirectly-elicited contractile tension of the soleus muscles of the neuropathic cats was not significantly lower than that in untreated animals. Amplitudes of spinal monosynaptic reflexes were unaffected. These data indicate, that in the cat, neurological impairment results partly from dysfunction in muscle spindles and peripheral nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319653
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  • 3
    Electronic Resource
    Electronic Resource
    A rapid sperm motility bioassay procedure for quality-control testing of water and culture media (1988)
    Springer
    Journal of assisted reproduction and genetics 5 (1988), S. 67-75 
    Details
    ISSN: 1573-7330
    Keywords: hamster sperm motility ; bioassay ; water purification ; culture media ; syringe filters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A rapid bioassay procedure is described for quality-control testing water and apparatus used in the preparation of media for gamete and embryo culture. This bioassay is based on the sensitivity of hamster epididymal spermatozoa to contaminants present in water and/or in the culture apparatus. The bioassay is usually performed using a modified Tyrode's solution as the sperm culture medium, although complex media can be used. The sensitivity of this test is greatly enhanced by the absence of protein in the medium. The bioassay has been used to detect impurities in water prepared by a standard cartridge filtration system and to verify that reverse-osmosis pretreatment of water could eliminate the problem. It has also detected toxic contaminants leached from syringe filters during medium sterilization. The bioassay is simple to perform and can be completed in 1 working day. It may be a useful alternative to the conventional mouse embryo tests that are in widespread use in human in vitro fertilization (IVF) laboratories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01130661
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  • 4
    Electronic Resource
    Electronic Resource
    A consistently successful procedure for in vitro fertilization of golden hamster eggs (1989)
    New York, NY : Wiley-Blackwell
    Gamete Research 23 (1989), S. 139-158 
    Details
    ISSN: 0148-7280
    Keywords: IVF ; sperm motility ; 2-cell embryos ; culture media ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Complete details are described for the first time of the procedures used in the author's laboratory for obtaining in vitro fertilization (IVF) of golden hamster eggs leading to the first cleavage division. These IVF procedures have been developed during the past 20 years and are very reproducible: IVF of at least 75% of eggs is routinely achieved, and on average 65% of inseminated eggs undergo the first cleavage division in vitro. These results can easily be obtained by inexperienced investigators. The ease and reproducibility of the hamster IVF procedures make them very suitable for studies of sperm:egg interaction and associated events. Studies in the author's laboratory have included analysis of sperm fertilizing ability under chemically defined conditions, the presence of sperm acrosome reaction stimulating factors in the egg investments, maturation of oocytes in vitro, the block to polyspermy, and the contribution of egg aging to fertilization anomalies. In addition, the motility of hamster sperm under chemically defined conditions is used in a routine screening protocol for detecting contaminants in the culture milieu. Golden hamster gametes of Ter several distinct advantages for IVF studies, including the large size of the sperm acrosome, the persistence of the very large sperm tail in the ooplasm for many hours following fertilization, and the translucence of the ooplasm, which facilitates observation of the sperm tail and pronuclei. The female golden hamster exhibits a regular 4 day estrous cycle, with distinctive indications of estrus and postestrus phases. Because of the advantages of using the golden hamster, the procedures described in this report may be useful to other investigators wishing to conduct research using IVF. Essentially the same IVF procedures can be used with monkey and bovine gametes.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1120230202
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  • 5
    Electronic Resource
    Electronic Resource
    Letters to the editor (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 18 (1994), S. 279-282 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610180405
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  • 6
    Electronic Resource
    Electronic Resource
    Calculation of kinetic rate constants from steady-state soil profile concentration measurements (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 17 (1993), S. 243-254 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: We derive a simple approximation for the steady-state distribution of solute subject to an arbitrary, irreversible transformation in a soil profile under the condition of steady fluid flow. The approximation accounts for the effect of dispersion in both the surface boundary condition and the transport equation. The accuracy of the approximation is determined explicitly for the cases of zero- and first-order kinetics, where exact solutions are available. Data from a numerical scheme are used to check the approximation's accuracy for the widely used Michaelis-Menten kinetic rate. It is shown that existing approximations in which the effect of dispersion in the transport equation is ignored can affect significantly the value determined for the Michaelis-Menten saturation constant. Parameters found when the new method is applied to experimental data are found to agree closely with those estimated directly from a least-squares fitting.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610170403
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  • 7
    Electronic Resource
    Electronic Resource
    Tensile stresses around boreholes due to transient fluid flow (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 17 (1993), S. 659-667 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: We present solutions for the effective stress induced by gas flow through a porous solid into a borehole resulting from sudden pressure reduction. Tensile effective stress that exceeds the strength of the solid will lead to borehole failure. This has applications to the intentional creation of cavities, relevant to the efficient recovery of coalbed methane, and the avoidance of borehole stability problems in conventional gas production.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610170905
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