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  • 1
    ISSN: 1432-1440
    Keywords: Malignant paraganglioma ; Recombinant interferon alfa ; Somatostatin-Analogue ; Alpha-methyl-para-tyrosin (MPT, Metyrosin)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present a case report on a 35-year-old patient in whom a malignant sympathetic paraganglioma of the organ of Zuckerkandl was the cause of severe hypertension with excessive perspiration at night. Since curative surgery was not possible medical treatment was initiated. Interferon alfa 2b (Intron A, Essex Pharma) and the somatostatin-analogue SMS 201–995 (Sandostatin, Sandoz) had no effect on catecholamine production and progression of the tumor. Treatment with alpha-methyl-para-tyrosin (MPT, [Metyrosin], Demser, MSD) turned out to be an effective and well tolerable therapy in this patient with peritoneal carcinosis. Clinical and hormonal progression of the paraganglioma resumed only after two years of therapy, which constitutes the longest documented period of time of successful MPT treatment. The superior efficacy of MPT in our patient should encourage postoperative medical treatment with MPT in malignant pheochromocytoma or malignant paraganglioma, particularly when the tumor turns out to be resistent to alpha blocking drugs.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 17 (1996), S. 276-288 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Schilddrüse ; Entzündung ; Autoimmunerkrankung ; Pathologie ; Key words Thyroid gland ; Inflammation ; Autoimmune disease ; Pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The aetiopathogenesis of auto-immune thyroid disease is still a matter for discussion. Morphologically, these illnesses are associated with a broad spectrum of overlapping changes. Thus, pathology cannot serve as the logical basis for a new classification. Therefore this overview makes use of the conventional nomenclature of clinically established entities and includes recently defined lesions. Besides histological characteristics, details of differential diagnostic value are presented in the context of clinical and laboratory data relevant for pathological classification.
    Notes: Zusammenfassung Die Ätiopathogenese der Immunthyreopathien ist unverändert Gegenstand der Diskussion. Morphologisch zeigen diese Erkrankungen ein breites Spektrum einander überlappender Veränderungen, so daß auch die Pathologie nicht die Basis für eine neue Klassifikation darstellen kann. Die vorliegende Übersicht basiert daher auf der konventionellen Systematik klinisch etablierter Entitäten einschließlich erst in jüngerer Zeit definierter Erkrankungsformen. Dargestellt werden neben histologischen Charakteristika differentialdiagnostisch bedeutsame Details vor dem Hindergrund für die pathologische Diagnostik relevanter klinischer und laborchemischer Befunde.
    Type of Medium: Electronic Resource
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