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  • 1
    Electronic Resource
    Electronic Resource
    Familial relapsing thrombotic micro-angiopathy in two siblings (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 99-101 
    Details
    ISSN: 1432-1076
    Keywords: Key words Familial recurrent ; thrombotic thrombocytopenia ; purpura ; Danazol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two siblings, a 12-year-old girl and a 7-year-old boy, had recurrent episodes of haemolytic-uraemic syndrome/thrombotic thrombocytopenic purpura, manifested mainly by thrombocytopenia and micro-angiopathic haemolytic anaemia. During 11 years of follow up the girl responded only to steroids, whereas many other therapeutic modalities were ineffective. Following treatment with low dose danazol relapses became fewer and of diminished severity and completely subsided after 6 months. The boy started his illness with signs of haemolytic uraemic syndrome and later developed neurological manifestations. During a 6 year follow up he responded only to plasma exchange. Althouth chronic thrombocytopenia persisted during the past 3 years, the boy's clinical condition improved. Conclusion A family with two children with recurrent episodes of thrombotic thrombocytopenic purpura is described. In one child danazol could have had a beneficial effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050383
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical studies with antibodies to myosins from the cytoplasm and membrane fraction of human blood platelets (1985)
    Springer
    Cell & tissue research 241 (1985), S. 399-404 
    Details
    ISSN: 1432-0878
    Keywords: Platelet membrane ; Platelet cytoplasm ; Myosin ; Enzyme immunoassay ; Immunofluorescence ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antibodies were raised to myosins extracted from the cytoplasm and solubilized membranes of human blood platelets. Both antibodies had similar titers as shown by enzyme-immunoassay and bound to the same sites as shown by immunohistochemistry. They were specific for cytoplasmic myosins (e.g., in human white blood cells, platelets and fibroblasts and rat endothelial cells). They showed no crossreaction with human or rat smooth muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217186
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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