ISSN:
1432-069X
Keywords:
Dithranol
;
Epidermal 12-HETE receptors
;
Down-regulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of dithranol and its therapeutically inactive oxidation product, danthrone, on 12(S)-HETE binding to the human epidermal cell line SCL-II were studied. Dithranol (0.25–1 Μg/ml), in contrast to danthrone, induced a substantial decrease in 12(S)-HETE binding in a dose-dependent manner. The inhibition occurred after a latency period of 6 h, reached its maximum at 18–24 h and slowly declined thereafter. At a concentration of 1 Μg/ ml, the drug led to an approximately 50% decrease in the number of specific high-affinity 12(S)-HEFE receptors (Bmax), whereas receptor affinity (Kd) showed no change. The down-regulation of 12(S)-HETE receptors on epidermal cells by dithranol may contribute to its antipsoriatic action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00376623
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