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Epstein-Barr virus serology in nasopharyngeal carcinomas and other head and neck neoplasms in Italy (1985)

Faggioni, A. ; Corradini, C. ; Barile, G. ; [et al.]

Springer

Journal of cancer research and clinical oncology 110 (1985), S. 157-160

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ISSN: 1432-1335

Keywords: Nasopharyngeal carcinoma ; Epstein-Barr virus ; Antibodies

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary This paper reports the results of the EBV-specific antibody response in 17 Italian nasopharyngeal carcinoma (NPC) patients, 15 other head and neck tumor patients and 15 normal controls. Nucleic acid hybridization has been performed on the biopsy tissue from 4 of the NPC patients, and EBV-DNA was present in two undifferentiated (WHO 3) tumors, and absent in two samples of the keratinizing (WHO 1) type. EBV serology appears to be specifically related to NPC, more evidently for VCA-IgA and EA-IgG antibodies, and useful as an aid in diagnosis of NPC. However, in order to assess a prognostic value of the above markers, a greater number of patients followed for a longer period of time (at least 5 years) is needed, and is currently being pursued.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00402731

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Human bone cell cultures: A new model for studying the mechanism of action of calcitonin (1985)

Fanó, G. ; Maurizi, M. ; Venti-Donti, G. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Cell Biochemistry and Function 3 (1985), S. 179-184

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ISSN: 0263-6484

Keywords: Human bone cell cultures ; calcitonin action ; 45Ca incorporation ; cyclic nucleotides ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: An investigation on cell cultures obtained from temporal human bone fragments showed that they provide a suitable model for studying the mechanism involved in calcitonin action on bone cells. Furthermore they demonstrated: (1) a transitory increase in 45Ca uptake that returned to control values ten minutes after the hormone was added; (2) a relation between 45Ca uptake and increased cAMP concentrations when these were measured at the same time intervals; (3) a reproduction of the salmon calcitonin (sCT) effect after incubation of the cultures with either db-cAMP or db-cGMP and (4) inhibition of 45Ca uptake and parallel decrease in cAMP levels with propanol.These results suggest that in human bone cell cultures, sCT acts as a temporary promoter of 45Ca uptake, probably by activating an adenylate-cyclase system through a β-receptor.

Additional Material: 4 Ill.