ISSN:
1437-7772
Keywords:
Key words FGF
;
Renal cell carcinoma
;
Tumor progression
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Background. Recently, several investigators have demonstrated that fibroblast growth factor-2 (FGF-2) plays a crucial role in the malignant progression of human renal cell carcinoma (RCC). However, the significance of other FGFs in RCC remains largely unknown. Methods. We investigated the expression of FGFs (FGF-1 to FGF-9) in 50 RCCs and surrounding ten normal kidney tissues using the reverse transcription-polymerase chain reaction (RT-PCR). We also analyzed the correlation between the incidence of FGF expression and the clinicopathological findings. Results. FGF-1, FGF-2, and FGF-9 were expressed in all the normal and malignant kidney specimens, whereas FGF-3, FGF-4, FGF-6, and FGF-7 were not detected in any specimens. FGF-5 and FGF-8 were expressed in all normal kidney tissues; however, FGF-5 was detected in only 27 of the 50 (54%) RCC specimens and FGF-8 was also detected in only 27 of the 50 (54%) RCC specimens. The incidence of FGF-5 expression in high-stage RCC was significantly greater than that in low-stage RCC (P 〈 0.01), whereas no significant difference was observed in the incidence of FGF-8 expression by tumor stage. In addition, the frequency of FGF-5 expression was significantly higher in the clear-cell subtype of RCC than in the granular-cell subtype (P 〈 0.05). Conclusion. We demonstrated a close relationship between the expression of FGF-5 and the development of RCC. Our result suggests that FGF-5 expression in RCC tissues may be a useful prognostic marker for this cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s101470050030
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