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  • Esophageal function Studies  (1)
  • Unterer Ösophagus  (1)
  • gastric acid secretion  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 293-297 
    ISSN: 1432-1440
    Keywords: Gastroösophagealer Reflux ; Potentialdifferenz ; Ösophagusfunktionstests ; Unterer Ösophagus ; Gastroesophageal Reflux ; Potential Difference ; Esophageal function Studies ; Lower Esophagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Esophageal electrical potential difference (PD) was studied in 9 patients with symptomatic gastroesophageal reflux and in 9 healthy control subjects. None of the patients revealed gross mucosal damage by radiography or endoscopy, but all of them showed positive acid perfusion studies. In the stomach and across the lower esophageal sphincter PD profiles were remarkably similar in patients and controls. Throughout the lower esophagus however, PD values were slightly higher in patients with symptomatic reflux than in healthy volunteers. These data are in contrast to a previous investigation, in which patients with reflux-induced gross mucosal damage revealed a decreased PD in the lower esophagus. Thus it is concluded that PD measurements of the lower esophagus do not appear to be a valuable test in the differentiation of chest pain of cardiac and esophageal origin.
    Notes: Zusammenfassung Bei 9 Patienten mit symptomatischem, gastroösophagealem Reflux und 9 gesunden Kontrollpersonen wurde die transmurale, elektrische Potentialdifferenz (PD) des Ösophagus gemessen. Radiologische und endoskopische Untersuchungen ergaben bei keinem der Patienten Hinweise für Veränderungen der Ösophagusschleimhaut, alle wiesen jedoch einen positiven Säureperfusionstest auf. Im Magen und im Bereich des unteren Ösophagussphinkter waren die PD Profile bei Patienten und Kontrollpersonen nahezu identisch. Im unteren Ösophagus wiesen Patienten mit gastroösophagealem Reflux jedoch deutlich höhere Potentialdifferenzen auf als gesunde Kontrollpersonen. Diese Ergebnisse stehen im Gegensatz zu einer vorhergehenden Untersuchung, in der Patienten mit makroskopischen Schleimhautveränderungen eine verminderte Potentialdifferenz im unteren Ösophagus aufwiesen. Diese voneinander abweichenden Ergebnisse bei Patienten mit erheblichen und geringen refluxbedingten Schleimhautveränderungen lassen die Schlußfolgerung zu, daß PD Messungen im Ösophagus keine empfindliche Methode für den Nachweis refluxbedingter Ösophagusveränderungen darstellen.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 26 (1984), S. 177-182 
    ISSN: 1432-1041
    Keywords: cimetidine ; ranitidine ; gastric acid secretion ; serum gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The purpose of the study was to evaluate the duration of inhibition of acid secretion by single oral doses of cimetidine and ranitidine. Basal and postprandial acid secretion in 6 healthy volunteers were measured for 14 h by intermittent aspiration and prolonged intragastric titration. 400 mg cimetidine reduced daytime acid secretion by 22% and 150 mg ranitidine produced 38% inhibition. Although the elimination half lives of the drugs were similar, ranitidine led to more pronounced inhibition of acid secretion during the later part of the day. The longer duration of pronounced acid inhibition by ranitidine appears to be due solely to its greater potency.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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