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  • 1
    Electronic Resource
    Electronic Resource
    Investigations of the estrogen (ER-ICA-test) and the progesterone receptor in the prostate and prostatic carcinoma on immunohistochemical basis (1988)
    Springer
    Virchows Archiv 412 (1988), S. 387-391 
    Details
    ISSN: 1432-2307
    Keywords: Estrogen ; Progesterone receptor ; Immunohistochemistry ; Prostate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Estrogen (ER) and Progesterone receptors (PR) were demonstrated immunohistochemically on frozen sections from 11 prostatectomy and 7 cystoprostatectomy specimens in the nuclei of various cell types. The periglandular fibrocytes and smooth muscle cells were extensively positive, the interglandular stromal cells were only partly so. Normal basal cells stained focally positive, hyperplastic basal cells stained extensively. The glandular secretory epithelium and atrophic glands were negative. The same findings were obtained in hyperplastic nodules. Both ER and PR also occurred in the urothelium of central prostatic ducts and of the prostatic urethra. The fibrous stroma around the ejaculatory ducts and seminal vesicles was extensively positive while the epithelium was negative. The smooth musculature of the seminal vesicles was only partly positive. On large field sections, the ER as well as the PR were numerically equally distributed throughout the inner zone of the prostate and the prostate proper. 12 prostatic carcinomas (G I–G III) were ER- and PR-negative. Estrogens may contribute to nodular hyperplasia by triggering a stromal proliferation with a secondary inductive epithelial growth. Obviously they do not act directly on prostatic carcinoma but inhibit growth via the hypophyseal-testicualr axis. The biological significance of the PR in the prostate is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00750267
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  • 2
    Electronic Resource
    Electronic Resource
    Glucocorticoid therapy obscures the diagnosis of cerebral lymphoma (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 629-634 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumor ; Non-Hodgkin lymphoma ; Primary cerebral lymphoma ; Stereotactic biopsy ; Glucocorticoid therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuropathological and radiographical findings of two patients with primary CNS B cell lymphoma are presented. Prior to computerized tomographic (CT)-guided stereotactic biopsy both patients had received glucocorticoid therapy which led to marked tumor regression on CT scans and transient improvement of neurological deficits. Despite careful targeting and serial sampling, multiple biopsy specimens examined cytologically, histologically and immunomorphologically showed nonspecific reactive astrogliosis and conspicuous perivascular infiltrates of T lymphocytes. A second biopsy performed after an interval of 2 and 8 weeks, respectively, and short-term discontinuation of dexamethasone therapy in one case, unequivocally established the diagnosis of Non-Hodgkin lymphoma. It is concluded that steroid therapy may obscure the bioptic diagnosis of cerebral lymphoma. In addition to the well-known anti-edematous effect of glucocorticoids neuropathologists and neurosurgeons should be aware of a rapid and pronounced lymphodepletive action of steroids on maligant CNS lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307631
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  • 3
    Electronic Resource
    Electronic Resource
    Hetero Analogs of SesquifulvaleneFrom the Habilitation Thesis by G. Seitz, Universität Marburg 1968, also Part 4 of Cyclopentadienylidenes. - Part 3: Tetrahedron Letters 1968, 2305. (1969)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 8 (1969), S. 478-482 
    Details
    ISSN: 0570-0833
    Keywords: Sesquifulvalenes ; Fulvalene ; Heterocycles ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Heterosesquifulvalenes containing sulfur or oxygen as hetero atom may be prepared, e.g., by condensation of cyclopentadienes with thiopyrones or pyrones in acetic anhydride. Heterosesquifulvalenes containing nitrogen can be obtained from the oxygen compounds by O,N-exchange. The ground state of all these compounds is determined mainly by the nonpolar resonance formula.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196904781
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    Paper (German National Licenses)
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