ISSN:
1432-2072
Keywords:
Ethanol-induced impairment
;
Renin-angiotensin system
;
Mineralocorticoid
;
Prostaglandin synthetase inhibitor
;
Furosemide
;
High salt-low salt diet
;
Spironolactone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Ethanol-induced motor impairment in rats was measured following a number of different dietary or drug treatments. A low sodium diet combined with injections of the diuretic furosemide, but not a low sodium diet alone, increased motor impairment while a high sodium diet decreased impairment. Blood ethanol measurements indicated that both effects were probably mediated by changes in blood ethanol levels. However, the synthetic mineralocorticoid, DOCA, and the nonsteroidal anti-inflammatory, indomethacin, both altered ethanol-induced motor impairment without concomitant changes in blood ethanol levels. The aldosterone antagonist, spironolactone, failed to produce any effect. Since all treatments can modulate activity in the renin-angiotension system, this system appears to play a role in altering some of the behavioral properties of ethanol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00431771
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