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  • 1
    Electronic Resource
    Electronic Resource
    The development of experimental brain tumours a sequential light and electron microscope study of the subependymal plate (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 177-185 
    Details
    ISSN: 1432-0533
    Keywords: Experimental gliomas ; Microtumours ; Ethylnitrosourea ; Subependymal plate ; Sequential fine structural study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pregnant BD-IX rats were given a single intraperitoneal injection of 30 mg of N-ethyl-N-nitrosourea (ENU) per kg of body weight on the 15th day of gestation. The offspring were killed at fortnightly intervals between 2 and 20 weeks of age. The subependymal plate region adjacent to the lateral ventricles was examined by light and electron microscopy to study the early stages in the development of brain tumours. Microtumours, composed of subependymal plate cells, glioblasts and various glial cells at different stages of maturation, were found in 16-, 18-, and 20-week-old rats. The most common site for microtumours was the angle of the lateral ventricles between the corpus callosum and caudate nucleus; others were located at the lateral aspect of the ventricles. It is suggested that most, if not all, cerebral gliomas originate from the undifferentiated cells of the subependymal plate: these mitotically active stem cells provide a susceptible target for the carcinogenic stimulus. The morphology of the gliomas developed is determined by the diverging processes of differentiation and anaplasia resulting in a pleomorphic cell population. The relevance of this experimental model to the pathogenesis of human gliomas is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702669
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fine structural localisation of acid phosphatase in neural tumours induced by N-ethyl-N-nitrosourea in rats (1974)
    Springer
    Acta neuropathologica 29 (1974), S. 45-55 
    Details
    ISSN: 1432-0533
    Keywords: Experimental Neural Tumours ; Ethylnitrosourea ; Electron Microscopy ; Lysosomes ; Acid Phosphatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A single intravenous injection of 30 mg of N-ethyl-N-nitrosourea per kg of body weight was administered to pregnant BD-IX rats on the 15th day of gestation. The neural tumours which developed in 97.5% of the offspring were gliomas and schwannomas. The demonstration of acid phosphatase in the neoplastic and reacting cells of these tumours was carried out at fine structural level. The enzyme activity was localised in lysosomes and in the innermost cisternae of the Golgi complexes. High acid phosphatase activity was related not only to degeneration, necrosis and phagocytosis but also to cellular differentiation and anaplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684390
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The fine structural localisation of thiamine pyrophosphatase and adenosine triphosphatase in neural tumours induced by N-ethyl-N-nitrosourea in rats (1974)
    Springer
    Acta neuropathologica 29 (1974), S. 199-209 
    Details
    ISSN: 1432-0533
    Keywords: Experimental Neural Tumours ; Ethylnitrosourea ; Electron Microscopy ; Thiamine Pyrophosphatase ; Adenosine Triphosphatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structural localisation of thiamine pyrophosphatase and adenosine triphosphatase was carried out in gliomas and schwannomas induced transplacentally by N-ethyl-N-nitrosourea. The activity of thiamine pyrophosphatase was observed in the Golgi complexes and appeared to be directly related to cellular differentiation and reactive changes. The Mg2+-dependent adenosine triphosphatase was localised at the cell membrane, in the pinocytotic vesicles of various cells and in the basement membrane of some capillaries. This enzyme, showing high activity in differentiated cells, indicated the activity of membrane-bound cellular transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685255
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Virus-like particles in brain tumours induced by N-ethyl-N-nitrosourea in rats (1974)
    Springer
    Acta neuropathologica 29 (1974), S. 211-222 
    Details
    ISSN: 1432-0533
    Keywords: Experimental Gliomas ; Ethylnitrosourea ; Electron Microscopy ; Virus-like Particles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two unusual, intracytoplasmic structures, resembling viruses, are described in experimental gliomas which were induced transplacentally on the 15th day of gestation in BD-IX rats by a single intravenous injection of 30 mg of N-ethyl-N-nitrosourea per kg of body weight. These structures are tubules within the lumen of the endoplasmic reticulum and large coated vesicles in the Golgi region. The tubules are of indeterminate length and have inner and outer walls of 9–11 nm and 20–22 nm respectively. The large coated vesicles are 80–90 nm in diameter and their outer surface is covered by regular, equidistant spikes of 12–15 nm in length. The vesicles are closely related to the Golgi complexes, from which they appear to originate. The intracisternal tubules and large coated vesicles share certain morphological features both with viruses and with normal cell organelles. The origin and significance of these structures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685256
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural localisation of sterols in ethylnitrosourea-induced schwannomas (1977)
    Springer
    Acta neuropathologica 40 (1977), S. 73-77 
    Details
    ISSN: 1432-0533
    Keywords: Transplacental carcinogenesis ; Ethylnitrosourea ; Schwannomas ; Free cholesterol ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Malignant schwannomas of the trigeminal nerves were induced transplacentally by a single intravenous injection of 30 mg of N-ethyl-N-nitrosourea per kg of body weight into pregnant BD-IX rats on the 15th day of gestation. These neoplasms consisted of a pleomorphic population of Schwann cells and occasional fibroblasts. In order to preserve sterols the tumours were fixed in a digitonin-containing aldehyde solution. The electron microscope investigation of the tissues so treated revealed various structures: lamellar, tubular and complex formations were all observed. In addition, the unit membranes, including those of various cytoplasmic organelles, showed areas of increased contrast. The abundance of these fine structural configurations indicated the high sterol content of ethyl-nitrosourea-induced schwannomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688575
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    An electron microscope study of reacting astrocytes in gliomas induced by N-ethyl-N-nitrosourea in rats (1974)
    Springer
    Acta neuropathologica 30 (1974), S. 175-181 
    Details
    ISSN: 1432-0533
    Keywords: Reacting Astrocytes ; Phagocytosis ; Experimental Gliomas ; Ethylnitrosourea ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of reacting astrocytes in experimental gliomas has been described. These tumours were induced transplacentally by 30 mg of N-ethyl-N-nitrosourea per kg of body weight injected into the tail vein of pregnant BD-IX rats on the 15th day of gestation. In tumour-bearing animals astrocytes undergo striking morphological changes and show increased mitotic activity. Reacting astrocytes around gliomas display large, eccentric, irregular nuclei and the abundant cytoplasm contains an increased number of cell organelles. The most dramatic increase is in glial filaments: these form thick bundles at the periphery of the cells and in the processes which are frequently seen around demyelinated axons. Reacting astrocytes engulf and break down myelin sheaths: their remnants, lamellar inclusion bodies and lipid droplets, are present in the cytoplasm. Extravasated erythrocytes are also surrounded by and digested in reacting astrocytes. Numerous lysosomes could provide the necessary enzymes for the phagocytic activity of these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685441
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The development of experimental brain tumours a sequential light and electron microscope study of the subependymal plate (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 167-175 
    Details
    ISSN: 1432-0533
    Keywords: Experimental gliomas ; Abnormal cell clusters ; Ethylnitrosourea ; Subependymal plate ; Sequential fine structural study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pregnant BD-IX rats were given a single intraperitoneal injection of 30 mg of N-ethyl-N-nitrosourea (ENU) per kg of body weight on the 15th day of gestation. The offspring were killed at fortnightly intervals between 2 and 20 weeks of age. The subependymal plate region adjacent to the lateral ventricles was examined by light and electron microscopy to study the early stages in the develoment of brain tumours. Abnormal clusters of undifferentiated subependymal plate cells were found in regions away from the plate from 8 weeks of age onwards. In addition focal cellular hyperplasia within the subependymal plate was also seen. These clusters, which often occurred around neurones and blood vessels, were thought to represent the earliest, morphologically detectable changes in the development of cerebral gliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702668
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    Paper (German National Licenses)
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