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  • Excitable media  (1)
  • Physical properties  (1)
  • Radionuklidtherapie  (1)
  • Retina  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Urologe 37 (1998), S. 162-166 
    ISSN: 1433-0563
    Keywords: Key words Prostate cancer ; Palliation ; Radionuclides ; Schlüsselwörter Prostatakarzinom ; Palliation ; Radionuklidtherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Patienten mit fortgeschrittenem Prostatakarzinom ist die suffiziente Therapie schmerzhafter Knochenmetastasen primäres, interdisziplinäres Behandlungsziel. Vorrangig erscheint die Erhaltung der Lebensqualität, nicht die Lebensverlängerung. Neben einer oralen Schmerzmedikation und lokalen Schmerzbestrahlung bieten systemische Radionuklidtherapien hilfreiche, risikoarme nuklearmedizinische Therapiealternativen in der Palliation schmerzhafter, multilokulärer osteoplastischer Knochenmetastasen. In Abhängigkeit vom gewählten Radiopharmazeutikum werden Ansprechraten und Schmerzreduktion in 65–80 % beschrieben. Die Dauer der Schmerzlinderung liegt im Mittel bei 6–12 Wochen. Während dieser Zeit kann die nebenwirkungsreiche, morphinhaltige Schmerzmedikation deutlich reduziert und in einigen Fällen ganz abgesetzt werden, was wiederum die Lebensqualität verbessert. Nach Abklingen der geringgradigen Myelodepression kann die Radionuklidtherapie wiederholt werden. Nachteilig bleibt allein der zweitägige stationäre Aufenthalt aufgrund geltender Strahlenschutzverordnung.
    Notes: Summary For patients with advanced prostate cancer efficient therapy of painfull bony lesions is the primary goal of interdisciplinary treatment strategies. Preservation of quality of life appears to be the main aim rather than prolongation of life. Apart from oral pain relief and local irradiation systemic treatment with radionuclides offers low-risk radiotherapeutic strategies for the palliation of painful, multifocal osteoplastic bone metastases. Depending on the radiopharmaceutical substance chosen response and reduction of pain are described in 65–80 %. The duration of pain relief lasts between 6–12 weeks. During this time the morphine based medication can be reduced and in some cases withdrawn which positively effects quality of life. After improvement of myelosuppression treatment with radionuclides can be repeated. Patients have to be hospitalized for two days because of protection from radiation procedures.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-0879
    Keywords: Key words Brushite stone ; Chemolysis ; Hemiacidrin ; Lithotripsy ; Physical properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because of their resistance to fragmentation, treatment of brushite stones is a big problem. This study was performed to look for an improvement in therapeutic strategies by using artificial stones made of brushite (Bon(n)-stones), which are comparable to their natural counterparts. Using an ultrasound transmission technique, longitudinal wave propagation speeds were measured at different time intervals during treatment with hemiacidrin. From these and density measurements, transverse wave speed, wave impedance and dynamic mechanical properties of the artificial stones were calculated. Moreover, the microhardness of artificial stones was measured and investigations on shock wave lithotripsy (SWL) combined with initial chemolytic treatment of the stones were performed. The suggestion was confirmed that stone fragility and thus SWL can be improved by varying the physical properties of brushite stones through treatment with hemiacidrin. Additionally, we demonstrated the efficacy of Suby G in dissolving artificial brushite stones using an experimental arrangement simulating the physiological conditions in the upper urinary tract. Moreover, the efficacy of four different intracorporeal lithotripsy devices (electrohydraulic, pneumatic, laser and ultrasound) was tested and it was shown that electrohydraulic lithotripsy seems to be the best system for comminution of brushite stones.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 115 (1997), S. 319-324 
    ISSN: 1432-1106
    Keywords: Key words Spreading depression ; Retina ; Self-organization ; Z-type rotation ; Excitable media
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Spreading depression (SD) of electroencephalographic activity is a dynamic wave phenomenon in the central nervous system (CNS). The retina, especially the isolated chicken retina, is an excellent constituent of the CNS in which to observe the dynamic behavior of the SD wave fronts, because it changes its optical properties during a SD attack. The waves become visible as milky fronts on a black background. It is still controversial what the basic mechanistic steps of SD are, but certainly SD belongs to the self-organization phenomena occurring in neuronal tissue. In this work, spiral-shaped wave fronts are analyzed using digital video imaging techniques. We report how the inner end of the wave front, the spiral tip, breaks away repeatedly. This separation process is associated with a Z-shaped trajectory (extension ∼1.2 mm) that is described by the tip over one spiral revolution (period 2.45±0.1 min). The Z-shaped trajectory does not remain fixed, but performs a complex motion across the retina with each period. This is the first time, to our knowledge, that established imaging methods have been applied to the study of the two-dimensional features of SD wave propagation and to obtaining quantitative data of their dynamics. Since these methods do not interfere with the tissue, it is possible to observe the intrinsic properties of the phenomenon without any external influence.
    Type of Medium: Electronic Resource
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