ISSN:
1432-0533
Keywords:
Experimental Allergic Neuritis
;
Unmyelinated “Antigen”
;
Schwann Cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The capacity of myelin-free Schwann cells to induce EAN was investigated. Human foetal peripheral nerve and human adult abdominal vagus nerve, both containing little or no myelin, failed to induce EAN when injected intradermally (together with Freund's adjuvant) into rabbits. In contrast, human adult sciatic nerve, which is heavily myelinated, induced characteristic signs and histopathology of EAN. Thus in the “myelin-free” “antigens” Schwann cell plasma membrane, from which myelin is apparently derived, failed to induce EAN. Reasons for this paradox are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687564
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