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  • Experimental allergic encephalomyelitis  (1)
  • Key words Central nervous system vasculature  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Evidence of persistent blood-brain barrier abnormalities in chronic-progressive multiple sclerosis (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 228-238 
    Details
    ISSN: 1432-0533
    Keywords: Key words Central nervous system vasculature ; Endothelium ; Mitochondria ; Morphometric analysis ; Pinocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Brain capillaries were analyzed morphometrically for alterations in organelle distribution and density in biopsy samples of central nervous system tissue from seven patients diagnosed as having chronic progressive multiple sclerosis. Data were expressed as percentage of endothelial cytoplasm occupied by the respective organelles. The density of pinocytotic vesicles in endothelium ranged from 0.53% within normal-appearing parenchyma to 1.2% in gliotic areas. For mitochondria the values ranged from 10.87% in normal areas to 4.72% in the same respective samples. Thus, an inverse correlation between vesicular and mitochondrial content was observed. These findings suggested that endothelial cells in gliotic areas are similar to endothelial cells of the systemic circulation in their mitochondrial content and pinocytotic activity. Interendothelial junctions in capillaries of all areas examined appeared normal. Additional evidence for a continuous blood-brain barrier anomaly in multiple sclerosis was the accumulation of perivascular fibrin, suggesting an increase in microvascular permeability. Perivascular collagen deposits, degenerative changes in pericytes and astrocytic swelling were also indicators of an increase in blood-brain barrier permeability. Taken together with previous data from experimental autoimmune encepha-lomyelitis, the present findings in chronic silent multiple sclerosis lesions suggest that central nervous system endothelial cells show persistent abnormalities of the blood-brain barrier, even in the absence of active inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296505
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental allergic encephalomyelitis (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 171-175 
    Details
    ISSN: 1432-0533
    Keywords: Central nervous system ; Autoimmunity ; Experimental allergic encephalomyelitis ; Lymphocytes ; Myelin ; Multiple sclerosis ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous studies have shown that Strain 13 guinea pigs sensitised for experimental allergic encephalomyelitis (EAE) as adults usually develop an acute, fatal form of disease while animals inoculated as juveniles usually display a chronic relapsing form. The present study reports that following repeated short-interval blood sampling by cardiac puncture for the estimation of lymphocyte populations, some adult Strain 13 guinea pigs sensitised for acute EAE unexpectedly survived and developed chronic EAE, while a group of juveniles sensitised for chronic EAE and bled under the same conditions, developed a more severe, acute form of EAE. It is suggested that this reversal of disease course was related to the depletion of circulating factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690517
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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