Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Stepwise development of a clinical expert system in rheumatology (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 139-144 
    Details
    ISSN: 1432-1440
    Keywords: Expert systems ; Computer-assisted diagnosis ; Decision support systems ; Evaluation studies ; Rheumatology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The evaluation of computer expert systems, a promising diagnostic tool for future application in clinical medicine, is of great importance. We present here the evaluation of our expert system, “RHEUMA”. It is stressed, that repeated retrospective testing and updating of an expert system and its subsequent repeated assessment in clinical use and surroundings is mandatory. This increases the diagnostic accuracy of the system. For our system this is demonstrated under three separate conditions. In the first study the information available for the computer system (mainframe) came from medical histories only. Here an error rate of about 25% — similar to that of physicians themselves using the same information — was observed in 358 outpatients, compared to the final diagnoses of physicians also relying solely on information from medical histories. In a second step a completely new system on a personal computer was developed with all relevant diagnostic information. The error rate of this system (0.4%) was much too optimistic because the knowledge base was changed during the study, affecting about 30% of the 282 prospectively recruited outpatients. In a third step the efficacy of the expert system was tested in an additional hospital without the diagnostic involvement of the first testing clinic. The error rate of the system without changing the knowledge base reached 11% in 51 outpatients in this rheumatology clinic. This result reflects the diagnostic accuracy of the system today. Its ability to specify the same diagnoses which clinical experts reached approached 90%. Considerable time is needed for such prospective testing, with repeated updating of the knowledge base — in our case for both the two systems and field studies of 2 years each. Further prospective field testing with physicians not specialized in rheumatology and with a larger number of patients is necessary before the system can be used in clinical routine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179995
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Expansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infection (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 393-396 
    Details
    ISSN: 1432-1440
    Keywords: T lymphocytes ; T lymphocytes, activated ; T lymphocytes, cytotoxic ; HIV ; AIDS ; Flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The phenotypic characterization of lymphocyte subsets in relation to different clinical stages of HIV infection has mainly focussed on CD4 and CD8 cells. Some reports focus on expansion of activated T lymphocytes in AIDS patients. Yet there is no detailed knowledge whether such changes occur also in earlier stages of HIV infection. In order to describe the kinetics and possible pathogenetic meaning of this subset when related to all distinct chronologic stages, we performed two-color flow cytometric lymphocyte differentiation in 173 HIV-infected patients and 30 healthy controls. All subjects were classified according to the Walter Reed (WR) system. Our results show that a significant increase of activated T lymphocytes (CD3+HLA/DR+) occurs early, in WR1 and WR2, thus preceding the clinically relevant CD4 depletion. This increase is paralleled by an expansion of CD 8+Leu7+cytotoxic cells. We conclude, thatearly changes of lymphocyte subsets are detectable in addition to inversion of the CD4/ CD8 ratio. The possible pathogenetic meaning including the question of possible autoimmune mechanisms is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01648577
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Immunsuppression durch Vitamin B6-Antagonisten (1979)
    Springer
    Research in experimental medicine 175 (1979), S. 169-180 
    Details
    ISSN: 1433-8580
    Keywords: Vitamin B6-Antagonists ; Immunosuppression ; Renal transplantation ; Vitamin B6-Antagonisten ; Immunsuppression ; Nierentransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In mehreren Versuchsserien wurde an 84 Inzuchtratten die Wirkung eines kombiniert-pharmakologisch-diätetischen Vitamin B6-Mangels auf die Abstoßung von Nierentransplantaten geprüft. Während bei den Kontrolltieren ohne Vitamin B6-Mangel über 90% der Tiere zwischen 7. und 13. Tag an einer abstoßungsbedingten Urämie eingingen, zeigten die behandelten und erfolgreich nierentransplantierten Ratten eine deutliche Verlängerung der Überlebenszeit. 17 von 38 Tieren (45%) lebten länger als 35 Tage. Pharmakologisch (Desoxipyridoxin) — in Kombination mit einer Vitamin B6-armen Diät — induzierter Vitamin B6-Mangel bietet somit die Möglichkeit einer — reversiblen — Immunsuppression.
    Notes: Summary The combined effect of Vitamin B6 free diet and 4-Desoxipyridoxin (a potent Vitamin B6-Antagonist) on the rejection reaction of inbred rats after renal transplantation was investigated. More than 90% of the control animals without Vitamin B6-deficiency died between 7 and 13 days with uremia due to an acute transplant rejection, where as the Vitamin deficient and successfully transplanted animals (n = 38) showed a significantly prolonged survival time. In 17/38 rats survival was longer than 35 days. Vitamin B6-deficiency, induced by Desoxipyridoxin and Vitamin B6-deficient diet offers the possibility of an effective and reversible immunosuppression in renal transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851824
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...