ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Acute intermittent porphyria with central pontine myelinolysis and cortical laminar necrosis (1999)

Susa, S. ; Daimon, M. ; Morita, Y. ; [et al.]

Springer

Neuroradiology 41 (1999), S. 835-839

add to mindlist on the mindlist

Details

ISSN: 1432-1920

Keywords: Key words Porphyria ; acute intermittent ; Encephalopathy ; porphyric ; Myelinolysis ; central pontine ; Necrosis ; cortical laminar ; Magnetic resonance imaging

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Acute intermittent porphyria (AIP) is an autosomal-dominant disease caused by a deficiency of porphobilinogen (PBG) deaminase. Patients with AIP present with neurological syndromes such as autonomic neuropathy, peripheral axonal neuropathy or central nervous system dysfunction. We report serial MRI of a patient with AIP who had cortical and subcortical cerebral changes. A 29-year-old woman with a 6-month history of AIP had an attack with severe hyponatraemia and generalised convulsions, treated with haem arginate and supportive therapy. MRI showed central pontine and extrapontine myelinolysis and cortical laminar necrosis. These are not common in AIP, but are likely to have been caused by rapid correction of hyponatraemia and by vasospasm, which could be induced by AIP.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002340050852

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Unique 3′-untranslated sequence of insulin-like growth factor-I isolated from human placenta (1991)

Daimon, M. ; Wang, C.-Y. ; Johnson, T. R. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 29 (1991), S. 238-244

add to mindlist on the mindlist

Details

ISSN: 1040-452X

Keywords: IGF-IA ; Long 3′-end ; Expression ; Transcripts sizes ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: A cDNA clone of 525 bp corresponding to the 3′-untranslated region of insulin-like growth factor-I was isolated from a human placenta library. The sequence of this clone extended 200 nucleotides downstream from the previously reported 3′-end of IGF-IA cDNA, indicating the existence of IGF-IA transcripts having an even larger 3′-untranslated region. By using this clone for RNA transfer blot hybridization, it was shown that this longer 3′-untranslated region is included in the 7.5- and 5.0-kb transcripts, but not in the 1.1- and 0.9-kb transcripts. It is also apparent that transcripts bearing the extended 3′-untranslated sequence are highly expressed in human placenta.

Additional Material: 4 Ill.