ISSN:
1432-2161
Keywords:
Premature epiphyseal fusion
;
Extramedullary hematopoiesis
;
Thalassemia
;
Hemoglobin synthesis
;
Low-transfusion regimen
;
Hypertransfusion regimen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The main skeletal abnormalities in β-thalassemia are widening of medullary spaces, rarefaction of bone trabeculae, thinning of cortical bone, and perpendicular periosteal spiculation. Premature epiphyseal fusion (PEF) and extramedullary hematopoiesis (EH) are found, though more rarely. The incidence of PEF and EH in 64 patients affected by β-thalassemia is reported. The different incidence of such complications in thalassemia major and intermedia is reported, and a possible correlation with transfusion regimen is also considered.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00351267
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