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  • FDA hydrolysing activity  (1)
  • Signal transduction pathways  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Xerocomus badius – Picea abies, an ectomycorrhiza of high activity and element storage capacity in acidic soil (1998)
    Springer
    Mycorrhiza 7 (1998), S. 267-275 
    Details
    ISSN: 1432-1890
    Keywords: Key words Ectomycorrhizas ; EELS ; Element accumulation ; Hyphal sheath ; ICP-AES ; FDA hydrolysing activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Mycorrhizas were collected from three Norway spruce (Picea abies) stands in southwest Germany, sorted on the morphotype level and analysed by fluorescein diacetate vital fluorescence staining and the accumulation of elements using inductively coupled plasma-atomic emission spectrometry (ICP-AES) and electron energy-loss spectroscopy (EELS). Xerocomus badius – Picea abies mycorrhizas showed a higher frequency of active hyphal sheaths and a higher potential to store nitrogen, phosphorus, potassium, magnesium, iron and zinc than other mycorrhizal types. Phosphorus and nitrogen were localized by EELS in vacuolar bodies which occurred consistently in the sheath of X. badius mycorrhizas. The results indicate that X. badius is well adapted to acidic stands and that its mycorrhizas are very efficient in uptake and storage of macronutrients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005720050191
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review (1999)
    Springer
    Cancer chemotherapy and pharmacology 44 (1999), S. 355-361 
    Details
    ISSN: 1432-0843
    Keywords: Keywords Apoptosis ; Antimicrotubule agents ; Bcl-2 phosphorylation ; Protein kinases ; Signal transduction pathways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Microtubules are important cytoskeletal components involved in many cellular events. Antimicrotubule agents including polymerizing agents (paclitaxel and docetaxel) and depolymerizing drugs (vincristine, vinorelbine, and estramustine phosphate) are widely used either alone or in combination with other anticancer drugs. These antimicrotubule agents are promoters of apoptosis in cancer cells. In this review, we discuss the role of bcl-2 family genes in the regulation of apoptosis, and summarize effects of microtubule targeting agents on apoptotic signal transduction pathways. Conclusion: Disruption of microtubule structure by antimicrotubule drugs results in induction of tumor suppressor gene p53 and inhibitor of cyclin-dependent kinases, p21WAF1/CIP1 (p21), and activation/inactivation of several protein kinases including Ras/Raf, PKC/PKA I/II, MAP kinases, and p34cdc2. These protein kinases are associated directly or indirectly with phosphorylation of bcl-2. Phosphorylation of bcl-2 and the elevations of p53 and p21 lead to apoptosis. New pathways of antitumor agents could be directed at this p53, p21 and bcl-2/bax function, and may enhance the effect of existing agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050989
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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