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  • FIBROSIS  (1)
  • FISH OIL  (1)
  • INFLAMMATION  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Dietary Supplementation of Nucleotides and Arginine Promotes Healing of Small Bowel Ulcers in Experimental Ulcerative Ileitis (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 1530-1536 
    Details
    ISSN: 1573-2568
    Keywords: LEWIS RATS ; NUCLEOTIDES ; ARGININE ; GLUTAMINE ; FISH OIL ; GUAR GUM ; ULCERS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We previously showed that intravenous totalparenteral nutrition supplemented with nucleosides andnucleotides (NS/NT) promoted ulcer healing in rats withindomethacin-induced ileitis. The present study evaluated whether dietary NT supplementationwould similarly affect ulcer healing in this model.Female Lewis rats were randomized into either control orexperimental groups receiving yeast RNA containing NT or arginine, glutamine, fish oil, guar gum,or a combination of yeast RNA + arginine diets. Ileitiswas induced by two doses of indomethacin (7.5 mg/kg)administered subcutaneously 24 hr apart. Ulcer number and length were determined at 4, 8, and 14 daysafter induction of ileitis. Ileal villous and cryptlength, crypt-villous ratio, and bromodeoxyuridine(BrdU) labeling were studied in the control and yeast RNA-supplemented diet groups. Ileal ulcerationwas present in all groups at 4 and 8 days and was almosthealed by 14 days. Rats receiving yeast RNA, arginine,and yeast RNA + arginine diets showed a significant decrease in ulcer number (56%, 28%, and 34%,respectively) and length (67%, 41%, and 48%,respectively) compared to controls at 8 but not at 4days. Glutamine, fish oil, and guar gum had no effect onulcer healing at 4, 8, or 14 days. Among thehistological parameters, a significant decrease in cryptlength in the yeast RNA-supplemented group at 8 dayssuggested an acceleration of the healing process and restoration to a near-normal crypt-villousarchitecture. We conclude that the yeast RNA, arginine,and yeast RNA + arginine diets accelerated ulcerhealing, as indicated by decreased ulcer number andlength. We postulate that the underlying mechanism(s)contributing to ulcer healing may be related, in part,to increased cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018887331672
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    AST/ALT Ratio ≥1 Is Not Diagnostic of Cirrhosis in Patients with Chronic Hepatitis C (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 2156-2159 
    Details
    ISSN: 1573-2568
    Keywords: FIBROSIS ; CIRRHOSIS ; INFLAMMATION ; HCV-RNA ; LIVER BIOPSY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Medical guidelines forinterferon-α2a or-α2b(IFN-α) treatment of chronic hepatitis C virus(HCV) infection depend upon baseline liver histology. Abetter long-term response to IFN-α therapy correlates with less inflammation and absenceof cirrhosis. It has been suggested that the presence ofcirrhosis in patients with chronic hepatitis C virusinfection may be predicted based on an AST/ALT ratio ≥1. This study was designed todetermine if the presence of cirrhosis can be predictedin patients with chronic HCV infection by such a ratio.Seventyseven patients, including 23 cirrhotics, withchronic HCV infection were studied. Serum ALT, AST, andHCV-RNA levels and hepatic activity index (HAI),reflecting histologic inflammation in all liverbiopsies, were assessed. AST/ALT ratios and mean ALT,AST, and HCV-RNA were determined for both cirrhoticand noncirrhotic patients. HAI was correlated with ALT,AST, and HCV-RNA levels, the latter determined byquantitative RT-PCR. The likelihood ratio (LR) and positive predictive value of an AST/ALT ratio≥1 for cirrhosis was 7.3 and only 77% , respectively.In cirrhotics vs noncirrhotics, there were nosignificant differences between mean serum ALT (149± 28 vs 176 ± 17 units/liter), AST (139± 28 vs 102 ± 8 units/liter), or HCV-RNAlevels (589,160 ± 147,053 vs 543,915 ±75,497 copies/ml), respectively. There was asignificant, but clinically weak, correlation between serum ALT and HAI (r =0.234), and none between HAI and either serum AST orHCV-RNA levels. Our results support the need for a liverbiopsy prior to treatment of chronic HCV infection, since the AST/ALT ratio fails to predictaccurately the presence of cirrhosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018888021118
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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