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  • 1
    Electronic Resource
    Electronic Resource
    Effects of propranolol on gastric mucosal perfusion and serum gastrin level in cirrhotic patients with portal hypertensive gastropathy (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 2433-2438 
    Details
    ISSN: 1573-2568
    Keywords: portal hypertensive gastropathy ; laser Doppler flowmetry ; propranolol ; gastrin ; pepsinogen I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastric mucosal hyperemia associated with elevated serum gastrin level has been suggested in cirrhotic patients with portal hypertensive gastropathy (PHG). Clinical evidence has shown that these patients may benefit from propranolol administration. The aim of this study was to investigate effect of propranolol on gastric mucosal perfusion and serum gastrin level in cirrhotic patients with portal hypertensive gastropathy. Gastric mucosal perfusion was assessed by laser Doppler flowmetry. Measurements were performed under basal conditions and after observer-blind administration of propranolol (30–60 mg/day,N=9) or placebo (N=9) for seven days. Placebo had no effect on either gastric mucosal perfusion or serum gastrin level. In contrast, propranolol administration significantly decreased both antrum gastric mucosal perfusion (from 0.88±0.28 to 0.73±0.26 V,P〈0.05) and corpus gastric mucosal perfusion (from 0.94±0.35 to 0.78±0.25 V,P〈0.05). However, this drug had no effect on serum gastrin level. We conclude that chronic propranolol administration in cirrhotic patients with portal hypertensive gastropathy may reduce gastric mucosal perfusion without changing serum gastrin level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087662
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serum Vascular Endothelial Growth Factor Levels in Various Liver Diseases (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 41-45 
    Details
    ISSN: 1573-2568
    Keywords: VASCULAR ENDOTHELIAL GROWTH FACTOR ; ACUTE HEPATITIS ; FULMINANT HEPATITIS ; VARIOUS LIVER DISEASES ; HEPATOCYTE GROWTH FACTOR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical significance of circulatingvascular endothelial growth factor (VEGF) in patientswith various liver diseases was investigated. Twenty-onepatients with acute hepatitis (AH), 40 with chronic hepatitis (CH), 34 with cirrhosis (LC), 16 withfulminant hepatitis (FH), 10 with primary biliarycirrhosis (PBC), 12 with autoimmune hepatitis (AIH), and120 healthy individuals were included. Serum VEGF levels were measured by a chemiluminescenceenzyme-linked immunosorbent assay. The mean values ofserum VEGF levels in the patients with AH, CH, LC, FH,AIH, PBC, and control were 172.7, 58.0, 44.1, 37.3, 49.7, 74.9, and 65.0 pg/ml, respectively. Thepatients with AH had a level of serum VEGF significantlyhigher than that of the control group (P 〈 0.001).The serum VEGF levels in survivors of FH weresignificantly increased, but not in the nonsurvivors in therecovery phase compared with the levels on admission (P〈 0.05). In the LC patients, serum VEGF levels weresignificantly lower than those of the control group (P 〈 0.05). These findings suggest thatserum VEGF level may be associated with hepatocyteregeneration grade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018863718430
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of nitroglycerin on portal pressure and gastric mucosal hemodynamics in patients with cirrhosis (1994)
    Springer
    Journal of gastroenterology 29 (1994), S. 180-188 
    Details
    ISSN: 1435-5922
    Keywords: portal hypertension ; nitroglycerin ; portal hypertensive gastropathy ; gastric mucosal hemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied 30 patients with cirrhosis to determine the effect of nitroglycerin on portal and gastric mucosal hemodynamics. Systemic hemodynamics, portal venous pressure (PVP), the hemoglobin index (IHB), and the oxygen saturation index (ISO2) of the gastric mucosa were measured before and after a continuous infusion of nitroglycerin. The patients were divided into two groups according to the presence or absence of major portal-systemic collateral routes on portograms. Nitroglycerin caused a reduction in PVP in all patients. Although there was no significant difference in systemic hemodynamic changes between the two groups, the reduction in PVP in patients with major portal-systemic collaterals was significantly higher than in those without major collaterals. A nitroglycerin infusion, at a dose of 1.0μg/kg per min for 10 min, produced a reduction in both IHB (−16%,P〈0.001) and ISO2 (−13%,P〈0.001) in the gastric mucosa, indicating gastric mucosal ischemia secondary to splanchnic vasoconstriction. These findings suggest that the continuous infusion of nitroglycerin reduces PVP in cirrhotic patients, particularly in those with major portal-systemic collaterals, and reduces the congestion of the gastric mucosa in patients with portal hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02358680
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    Paper (German National Licenses)
    Fulltext
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