ISSN:
1573-2568
Keywords:
LATE-STAGE ALCOHOLIC CHRONICPANCREATITIS
;
TUMOR NECROSIS FACTOR-α
;
SOLUBLE TUMOR NECROSIS FACTOR RECEPTORS
;
FUNCTIONAL ACTIVITY
;
PERIPHERAL BLOOD MONONUCLEAR CELLS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The exact immunological mechanisms underlyingalcoholic chronic pancreatitis are unclear. Toinvestigate the role of the tumor necrosis factor (TNF)receptor pathway the serum levels of TNF-α,soluble TNF receptors-p55/-p75, and CRP were determinedby ELISA in 34 patients with late-stage alcoholicchronic pancreatitis and 28 controls. The diseaseactivity (Balthazar scoring system) of acutepancreatitis on the background of late-stage chronicpancreatitis correlated with an increase of functionallyactive TNF receptor-p55/-p75 serum levels. Unstimulatedperipheral blood mononuclear cells are one source of soluble TNF receptors and demonstrated asystemic leukocyte activation. The marked enhancement ofsoluble TNF receptors suggests that alcoholic chronicpancreatitis may be characterized by transient peaks of in situ TNF-α productionpreceding a long-lasting release of soluble TNFreceptors. The data demonstrate immunological changescharacteristic of acute pancreatitis in late-stagealcoholic chronic pancreatitis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018822101845
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