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  • 1
    Electronic Resource
    Electronic Resource
    The value of screening and central registration of families with familial adenomatous polyposis (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 227-230 
    Details
    ISSN: 1530-0358
    Keywords: Familial adenomatous polyposis ; National registry ; Screening ; Age at diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 1984 a national registry of families with familial adenomatous polyposis was set up in The Netherlands to promote screening in those families. Eighty-two families had been registered by the end of 1988. Analysis of the pedigrees showed that 204 family members at risk had not yet been screened. The diagnosis of familial adenomatous polyposis was histologically confirmed in 230 patients. These patients were subdivided into two groups. Group A comprised patients with familial adenomatous polyposis referred because they were symptomatic, and Group B relatives of these patients who were found by screening to have familial adenomatous polyposis. The authors compared these groups with respect to the occurrence of colorectal carcinoma. Fifty-four patients were found to have a colorectal carcinoma at the time of diagnosis of familial adenomatous polyposis,i.e.,49 of the 104 patients in Group A (47 percent) and five of the 126 patients in Group B (4 percent). The average age at diagnosis of the 104 patients in Group A was 35 years (range, 13 to 66 years) and that of the 126 patients in Group B was 24 years (range, 8 to 59 years). By the age of 40 years, 90 percent of the patients in group B had been diagnosed. Late onset of familial adenomatous polyposis was found in four families. Endoscopy and/or radiography of the upper digestive tract were (was) performed in 44 of the 230 patients. Nineteen patients (43 percent) were found to have polyps in the stomach or duodenum, or both. In our series, only one patient died from cancer of the upper digestive tract (ampullary carcinoma). These results show conclusively that screening leads to the early detection of familial adenomatous polyposis. The value of a national registry is proved by the finding of many at-risk family members who had not previously been screened. Screening should start between the ages of 10 and 12 and should continue up to the age of 50. In the rare cases of families with an apparently late onset of familial adenomatous polyposis, screening should be continued up to age 60. More studies are needed to determine the natural history of polyps in the upper digestive tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02134185
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Superoxide dismutases in the human colorectal cancer sequence (1999)
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 327-335 
    Details
    ISSN: 1432-1335
    Keywords: Key words Adenomas ; Colorectal cancer ; Liver metastases ; Superoxide dismutases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Purpose : The oxidant-antioxidant balance within tissues is thought to contribute to the development and progression of cancer. Previous investigations have indicated changes in this balance during the colorectal oncogenic process that merit further investigation. The aim of the present study was to evaluate whether the human colorectal cancer sequence is accompanied by changes in the protein and activity levels of the antioxidant enzymes manganese- and copper/zinc-superoxide dismutase (Mn-SOD and Cu/Zn-SOD). Patients and methods : SOD levels were assessed in colorectal adenomas, carcinomas, and liver metastases and were compared with those in the corresponding normal tissues (n=35 in each group). Mn- and Cu/Zn-SOD expression was first evaluated semiquantitatively by electrophoretic activity analysis, immunoblotting, and immunohistochemistry and was subsequently quantified by enzyme-linked immunosorbent assays (ELISAs) and spectrophotometric activity assays. Results : The semiquantitative analyses showed enhanced Mn-SOD levels, primarily localized in (neoplastic) epithelial cells, in carcinomas, and in liver metastases as compared with adenomas and normal mucosa, whereas no consistent pattern was observed for Cu/Zn-SOD. Normal liver tissue expressed the highest levels of both SODs. The quantitative SOD analyses confirmed these observations and revealed that carcinomas and liver metastases expressed 2–4 times more Mn-SOD protein and enzymatic activity (0.0005 〈 P ≤ 0.01) than did the normal mucosa. Adenomas expressed intermediate Mn-SOD levels, which increased significantly with the diameter and tended to increase with the grade of dysplasia and presence of a villous component. In contrast, adenomas, carcinomas, and the corresponding normal mucosa were found to have a similar Cu/Zn-SOD content, whereas liver metastases contained significantly (P 〈 0.02) more Cu/Zn-SOD as compared with these tissues. In addition, the Cu/Zn-SOD content was not related to any histopathological characteristic of the carcinomas or adenomas. Conclusions : Our study indicates that the development of neoplasia in the human colorectum is accompanied by major changes in the level and activity of Mn-SOD. This observation illustrates that Mn-SOD might have a functional role in human colorectal carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050282
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inflammatory Bowel Disease Activity Assessment Using Technetium-99m-HMPAO Leukocytes (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 387-393 
    Details
    ISSN: 1573-2568
    Keywords: TECHNETIUM-99M ; LEUKOCYTES ; HEXAMETHYL-PROPYLAMINE-OXIME ; INFLAMMATORY BOWEL DISEASE ; INFLAMMATION ; SCINTIGRAPHY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aim of the study was to evaluate[99mTc]hexamethyl-propylamine-oxime (HMPAO)leukocyte scintigraphy for the assessment of diseaseactivity and extent in inflammatory bowel diseasepatients. Results and scores of scintigraphy using[99Tc]HMPAO-labeled leukocytes wereretrospectively compared with the activity index of vanHees, laboratory parameters, and gastroenterologists'assessment of disease using endoscopy, radiology, and histology plusclinical parameters in 136 patients with Crohn's disease(115) and ulcerative colitis (21) and in 29 controls.There were 114 positive and 22 negative[99Tc]HMPAO leukocyte scintigrams. Sensitivities for activedisease at 1 and 3 hr were 98% and 98% and specificitieswere 100% and 83%, respectively. [99mTc]HMPAOleukocyte scintigraphy is superior to the activity index and the gastroenterologists' clinicalassessment of active inflammation in IBD patients.Scintigraphy allows assessment of the existence, extent,and intensity of active inflammation in IBD patients in one examination with highaccuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018834406637
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    Paper (German National Licenses)
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