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  • Harmaline  (2)
  • Fastigial nucleus, [14C]-2-deoxyglucose  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cerebellar output response to afferent stimulation: Energy consumption and unit activity in the cat fastigial nucleus (1983)
    Springer
    Experimental brain research 52 (1983), S. 400-410 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellum ; Fastigial nucleus, [14C]-2-deoxyglucose ; Unit activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cerebellar output function was studied using cerebellopetal proprioceptive stimulation hich produces simple and complex excitatory discharges as well as inhibitory activity in the Purkinje cells. The activity of the intracerebellar nuclei (and of the entire brain stem) was measured by the energy consumption as revealed with the [14C]-2-deoxyglucose method. The stimulations consisted of repetitive (1–20 c/s) electrical excitation of the nerve leading to the inferior oblique, to the masseteric and to the gastrocnemius soleus muscle. Compared to a group of non-stimulated controls, heavy bilateral labeling was obtained in the posterior pole of the fastigial nucleus. This was not observed with stimulation of the vibrissal pad which, however, produced a clear increase of [14C]-2-deoxy glucose uptake in the secondary trigeminal complex. Labeling of the posterior part of the fastigial nuclei was suppressed by ablation or pharmacologic inactivation of the overlying cerebellar cortex which suppresses the inhibitory activity of the Purkinje cells into the nuclear cells. Labeling of the posterior fastigial nuclei was also decreased in animals not stimulated but with ablation or pharmacologic inactivation of the overlying cerebellar ortex. The hypothesis proposed is that the marking results are the consequence of an increased activity in the Purkinje cell terminals. The activity of the Purkinje cells was also recorded extracellulary both before and during repetitive stimulation of a muscle nerve. The discharge activity of those in the cerebellar vermis and giving axons to the posterior fastigial nucleus was increased by the stimulation, whereas the activity of those of the hemispheral parts remained unchanged. Units in the fastigial nucleus were also recorded. Their activity was found to be deeply depressed so that only a few units were encountered and no further decrease of their discharge could be detected with the stimulation of a muscle nerve. Nevertheless, using the present data and those previously obtained, the conclusion is advanced that the cerebellar output function is actually decreased during afferent cerebellar stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238033
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Harmaline-induced tremor (1981)
    Springer
    Experimental brain research 42 (1981), S. 383-391 
    Details
    ISSN: 1432-1106
    Keywords: Harmaline ; Tremor ; Interposito ; Rubral system ; Oculomotricity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Units were recorded extracellulary in the cat brainstem under the effect of tremogenic doses of harmaline. They were localized post mortem and the units discharging at the harmaline tremor frequency were mapped. Harmaline-sensitive neurons were found in the bulbo-pontine reticular formation, in particular, in the lateral reticular nucleus and the nucleus reticularis tegmenti pontis. The nucleus interpositus as well as the red nucleus also displayed numerous units discharging at the tremor frequency, indicating that the cerebello-interposito-rubro-spinal system controlling the flexor muscles participate in harmaline tremor. Participation of the oculomotor system in the harmaline-induced tremor was tested at the level of the vestibular neurons relaying the vestibulo-ocular reflex, the motoneurons, the eye muscles and the eye movements. No rhythmic discharge at the tremor frequency nor eye movements could be detected, indicating that harmaline tremor does not affect the oculomotor system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237503
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Harmaline-induced tremor (1981)
    Springer
    Experimental brain research 42 (1981), S. 371-382 
    Details
    ISSN: 1432-1106
    Keywords: Harmaline ; Tremor ; Inferior olive ; Cerebellum ; Deoxyglucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes of local cerebral glucose consumption under the effect of tremogenic doses of harmaline were studied. To find the brain structures activated by the drug, the autoradiographic method using [14C]2-deoxyglucose was applied to young cats. After administration of harmaline, the animals were paralized with flaxedil. Results were compared to a group of control animals not injected with the drug, but submitted to the same experimental protocol. Increases of neuronal activity were observed in several structures. A) Among the relays of the olivo-cerebellofastigio (and vestibulo)-reticulo-spinal circuit that had been claimed to fire at the frequency of the tremor, labeling was found in: 1. selected portions of the inferior olive including the medial accessory olive and the caudolateral part of the dorsal accessory olive; 2. the molecular layers of the cerebellar cortex including vermian and paravermian zones. Labeling of the olivo-cerbellar system was therefore larger than the compartment controlling the fastigial nucleus and extended to that controlling the interpositus nucleus. B) Other structures not under the direct control of the olivo-cerebellar system displayed increased radioactivity under harmaline: lateral reticular nucleus, nucleus reticularis tegmenti pontis, red nucleus and basal ganglia. Part of nucleus ambiguus, intensely labeled in the control animals, showed decreased radioactivity under harmaline. The experiments were repeated with the same protocol in another group of animals with unilateral sections of the inferior cerebellar peduncle in order to distinguish between a direct pharmacological influence and a nervous one. Marking of the basal ganglia was not affected by pedunculotomy, suggesting a direct “pharmacological” action of the drug in this cases. On the other hand, marking of the other labeled structures was asymmetric or suppressed by pedunculotomy, and therefore could result from a “nervous” effect secondary to activation of the inferior olive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237502
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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