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  • 1
    Electronic Resource
    Electronic Resource
    Plasma fibronectin concentrations in blood products (1990)
    Springer
    Intensive care medicine 16 (1990), S. 41-43 
    Details
    ISSN: 1432-1238
    Keywords: Fibronectin ; Blood products ; Mononuclear phagocyte system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma fibronectin is an important opsonic protein of the mononuclear phagocyte system (MPS). In this study, plasma fibronectin concentrations were measured in stored and fresh whole blood, fresh frozen plasma and AGH cryoprecipitate. Stored whole blood had the lowest concentrations (151±50 mg/l). The concentrations in fresh whole blood plasma (227±66 mg/l) and fresh frozen plasma (224±78 mg/l) were similar but significantly higher than in stored whole blood (p〈0.05). In contrast, AHG cryoprecipitate had the highest fibronectin concentrations (3249±502 mg/l) (p〈0.001). In correcting fibronectic deficiency the best results can thus be expected from an infusion of cryoprecipitate, but fresh whole blood and fresh frozen plasma may also increase depressed fibronectin levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01706323
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Propofol emulsion reduces proliferative responses of lymphocytes from intensive care patients (1993)
    Springer
    Intensive care medicine 19 (1993), S. 299-302 
    Details
    ISSN: 1432-1238
    Keywords: Anesthetics ; Propofol ; Fat emulsion ; Lymphocyte transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To test propofol lipid emulsion formulation for its immunosuppressive effects. Design Propofol lipid emulsion and the emulsion alone were tested at increasing concentrations and compared to initial values and between each other. Propofol alone could not be tested due to its insolubility into the culture medium. Patients and participants Lymphocytes from 12 surgical intensive care (ICU) patients (median APACHE score 16 and median TISS score 28) and 12 healthy volunteers. Measurements Phytohaemagglutinin-, concanavalin A-and pokeweed mitogen-induced lymphocyte proliferative responses were measured in the presence of increasing concentrations of propofol lipid emulsion formulation or the lipid emulsion. Results Lymphocyte proliferative responses from ICU patients were in general on a lower level than in the volunteers. The propofol lipid emulsion formulation (Diprivan®) decreased pokeweed mitogen-induced proliferative responses of lymphocytes from ICU patients at propofol concentrations found in the circulation (1–10 μg/ml) and the lipid emulsion alone at 100 μg/ml triglyceride concentrations while the other mitogen-induced responses were not affected. No changes were observed in the mitogen-induced responses of lymphocytes from healthy volunteers. Conclusions Propofol emulsion formulation decreased in surgical intensive care patients pokeweed mitogen-induced lymphocytic responses in vitro at clinically found concentrations, indicating the need for further studies to test B-lymphocyte functions and T-B-lymphocyte co-operation during propofol lipid emulsion administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01690552
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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