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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 38 (1980), S. 221-227 
    ISSN: 1432-1106
    Keywords: Basal ganglia ; Choreoathetosis ; Insecticides ; Electroencephalogram ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Decamethrin (NRDC 161) is a neurotoxic pyrethroid insecticide which produces a reversible sequence of motor symptoms in rats involving hind limb rigidity and choreoathetosis. This paper represents an evaluation of the usefulness of decamethrin as an experimental method of inducing extrapyramidal hyperexcitability. EEG records from conscious rats showed a specific slowing of movement related θ activity to parallel the development of hind limb rigidity, but no discernible change in other components until shortly before the onset of choreoathetosis. At this point localised sharp waves could be evoked by sensory stimuli. These developed rapidly into spontaneous generalised spike sequences which followed individual spasms. Cortical auditory evoked potentials were decreased in amplitude during this phase. Depth electrodes showed discharges initially in the globus pallidus and caudate nucleus which spread to the frontal cortex and thence to the rest of the cortex and to other areas. During continued spontaneous choreoathetosis spikes and slow wave activity developed, dominating all records until recovery or death. In anaesthetised rats extracellular unit records from cells in the caudate nucleus showed a rapid increase in firing rate after intravenous decamethrin as EEG spikes developed. Cortical somato-sensory evoked potentials were decreased in amplitude as in the conscious rats but with additional development of a sharp late component during generalised EEG spiking. It is concluded that the symptoms, distribution, and nature of cortical and subcortical spiking, supression of cortical evoked responses, and increase in caudate neuronal activity all are consistent with a primary action of decamethrin upon the extrapyramidal motor system.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 36 (1992), S. 141-145 
    ISSN: 1432-1254
    Keywords: Fertility ; Microclimates ; Heat stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Records were obtained over a 3 year period from six Holstein dairy farms of 300 to 500 cows each in the Phoenix, Ariz. area. Dairies were selected on the basis of similar management practices, herd size, milk production and facilities (with the exception of cooling systems). Microclimatic modifications (two dairies each) were shade only (approximately 3.7 m2/cow), evaporative-cooled shades and low-pressure water foggers under the shades. Data were categorized by season of calving (spring, Feb.–May; summer, June–Sept.; and fall, Oct.–Jan.). Traits evaluated were calving interval, days open and services/conception. Calving interval was shortest for cows calving in the spring (378 days), intermediate in fall (382 days) and longest in summer (396 days). Similar seasonal trends were observed for days open (103, 103 and 119 days, respectively) and services/conception (1.54, 1.81 and 1.93, respectively). All differences between spring and summer were significant (P 〈 0.05). Calving interval and days open were less for evaporative-cooled groups (374 and 98 days, respectively), with no difference between shade only and foggers (391 and 392 days, 112 and 116 days, respectively). Services/conception were similar for all groups (1.72 to 1.79). A significant interaction between microclimate and season for services/conception could be interpreted as (i) smaller season differences for evaporative-cooled groups than for shade or foggers, or (ii) a change in the ranking of control and fogger groups during summer versus fall. Evaporative cooling was more effective than fogging for reducing the detrimental effects of seasonal high temperatures on fertility.
    Type of Medium: Electronic Resource
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