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  • 1
    Electronic Resource
    Electronic Resource
    Effects of doxazosin and atenolol on the fibrinolytic system in patients with hypertension and elevated serum cholesterol (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 321-326 
    Details
    ISSN: 1432-1041
    Keywords: Fibrinolysis ; hypertension ; atenolol ; doxazosin ; tissue plasminogen activator ; plasminogen activator inhibitor ; cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Disturbances in the fibrinolytic system have been associated with cardiovascular disease and its risk factors. In the present study the effects of an alpha1-adrenoceptor inhibitor (doxazosin) and a selective beta-adrenoceptor blocker (atenolol) on the fibrinolytic system have been evaluated. Eighty four subjects with previously untreated mild to moderate hypertension and elevated serum cholesterol were randomized to receive atenolol or doxazosin in a double-blind study over 6 months. Tissue plasminogen activator(tPA) and plasminogen activator inhibitor (PAI-1) were measured in citrated plasma samples before and after venous occlusion before and at the end of the study period. tPA activity after venous occlusion and tPA capacity were significantly increased after doxazosin as compared to pretreatment values. The fibrinolytic variables did not change in the atenolol group. Thus, doxazosin but not atenolol, improved the activity of the fibrinolytic system in patients with hypertension and an elevated serum cholesterol level. This effect of doxazosin warrants consideration when selecting a first-line antihypertensive drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265838
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Enalapril related changes in the fibrinolytic system in survivors of myocardial infarction (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 485-488 
    Details
    ISSN: 1432-1041
    Keywords: Fibrinolysis ; Tissue plasminogen activator ; Enalapril ; plasminogen activator inhibitor ; acute myocardial infarction ; ACE-inhibitor ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Disturbances of the fibrinolytic system have been associated with cardiovascular disease and its risk factors. In the present study the effects of an ACE-inhibitor (enalapril) and a placebo on the fibrinolytic system have been compared. Eighty one survivors of acute myocardial infarction were randomised to treatment with enalapril or placebo. The mass concentrations and activity of tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-1) in plasma were measured three months after the infarction. The enalapril group had a significantly lower level of tPA antigen compared to the placebo-treated group (9.2 and 10.6 respectively). There was no difference between the two groups in any of the other fibrinolytic variables. We conclude that survivors of myocardial infarction treated with enalapril have a significantly lower concentration of tPA antigen than those treated with placebo. This may have a prognostic implication, as lower plasma concentrations of tPA antigen have been associated with better prognosis in patients with established coronary heart disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315549
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Tissue plasminogen activator, plasminogen activator inhibitor-1 and von willebrand factor in rheumatoid arthritis (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 318-324 
    Details
    ISSN: 1434-9949
    Keywords: Tissue Plasminogen Activator ; Plasminogen Activator Inhibitor-1 von Willebrand Factor ; Fibrinolysis ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), all of endothelial origin and active in the haemostasis, were analysed in 74 patients with rheumatoid arthritis. The concentrations were related to extra-articular disease and to the incidence of thromboembolic events (TE) registered in a 2-year follow-up period. Patients with extra-articular disease had a significant increase in PAI-1 activity and reduced tPA release in the venous occlusion test. von Willebrand factor, PAI-1 and also haptoglobin and triglycerides were significantly increased in the group of patients who later suffered from TE. In a multiple regression model, in which cholesterol, triglycerides and lipoprotein (a) showed significant association with TE, vWF had the strongest additive explanatory value. No distinct acute phase pattern of PAI-1 was found in any patient subgroup.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231572
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Decreased fibrinolytic capacity and increased von Willebrand factor levels as indicators of endothelial cell dysfunction in patients with lupus anticoagulant (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 58-63 
    Details
    ISSN: 1434-9949
    Keywords: Autoimmunity ; Fibrinolysis ; Lupus Anticoagulant ; Thrombosis ; Tissue Plasminogen Activator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Over a 6-year period, 10 patients with lupus anticoagulant activity were seen. A history of thrombotic disease was found in 6 patients, but only 3 had systemic autoimmune disease. Reduced fibrinolytic activity after venous occlusion was found in 9 subjects, but only 4 had high von Willebrand factor levels. These changes were unrelated to inflammatory activity, which was ruled out by normal serum protein electrophoresis in all but one case. Human brain thromboplastin dilution test was pathological in all subjects with depressed fibrinolytic activity. These two tests may prove to be of value to single out those LA patients with highest risk for development of thromboembolic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02031071
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    Paper (German National Licenses)
    Fulltext
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