Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    An improved isolated, left ventricular ejecting, murine heart model (1999)
    Springer
    Pflügers Archiv 437 (1999), S. 182-190 
    Details
    ISSN: 1432-2013
    Keywords: Key words Isolated murine heart ; Antegrade perfusion ; Functional stability ; High-energy phosphates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  An improved, isolated, left ventricular-ejecting, murine heart model is described and evaluated. Special attention was paid to the design and impedance characteristics of the artificial aortic outflow tract and perfusate composition, which contained glucose (10 mM plus insulin) and pyruvate (1.5 mM) as substrates. Temperature of the isolated perfused hearts was maintained at 38.5 °C. During antegrade perfusion (preload 10 mm Hg, afterload 50 mm Hg, 2.5 mM Ca2+) proper design of the aortic outflow tract provided baseline values for cardiac output (CO), left ventricular developed pressure (LVDP) and the maximum first derivative of left ventricular pressure (LV dP/dt max) of 11.1±1.7 ml min–1, 83±5 mm Hg and 6283±552 mm Hg s–1, respectively, resembling findings in the intact mouse. During 100 min normoxic antegrade perfusion CO declined non-significantly by less than 10%. Varying pre- and afterloads resulted in typical Frank-Starling relationships with maximal CO values of 18.6±1.8 ml min–1 at pre- and afterload pressures of 25 and 50 mm Hg, respectively. Left ventricular function curves were constructed at free [Ca2+] of 1.5 and 2.5 mM in the perfusion medium. Significantly higher values for CO, LVDP and LV dP/dt max and LV dP/dt min were obtained at 2.5 mM Ca2+ at all loading conditions investigated. Phosphocreatine and creatine levels remained stable throughout the perfusion period. Despite a small but significant decline in tissue ATP content, the sum of adenine nucleotides did not change during the normoxic perfusion period. The tissue content of glycogen increased significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050767
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    On the consistency of four different control surfaces used for finite area blade-to-blade flow calculations (1984)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 4 (1984), S. 1083-1095 
    Details
    ISSN: 0271-2091
    Keywords: Turbomachines ; Finite Volume ; Consistency ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The aim of this contribution is to investigate the consistency and order of accuracy of different control surfaces used for finite area blade-to-blade flow calculations. The following cases will be treated: a hexagonal element, a trapezoidal element, a bitrapezoidal element and a quadrilateral element. Finally, the consistency conditions will be discussed and compared with respect to a cascade flow application.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650041107
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...