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  • 1
    Electronic Resource
    Electronic Resource
    Generation of cytotoxic effector cells against human melanoma (1995)
    Springer
    Cancer immunology immunotherapy 40 (1995), S. 397-409 
    Details
    ISSN: 1432-0851
    Keywords: Generation ; Lymphocytes ; Melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Metastatic or tumor-draining lymph nodes from six of nine melanoma patients undergoing lymph node dissection for metastatic melanoma generated cytotoxic T cells against autologous melanoma when these lymph node cells were treated by in vitro sensitization and recombinant interleukin-2 (IL-2). During the initial lymphocyte culture (2–6 weeks), cross-reactivity with autologous tumor cells, K562 and Daudi cells was usually noted. Cold-target inhibition assay with K562 and Daudi showed K562/Daudi-associated antigens on melanoma cells. During the later phase of lymphocyte culture with repeated in vitro sensitization (over 6–10 weeks), cytotoxicity was noted against autologous and allogeneic melanoma cells but not against K562, Daudi cells or autologous fibroblasts. Repeated in vitro sensitization resulted in the selection of specific cytotoxic lymphocytes against melanoma. Cold-target inhibition assay with autologous and allogeneic melanoma cells revealed shared and individual antigens. Using blocking monoclonal antibodies, MHC-restricted killing was noted in the autologous system. Further, both the autologous and allogeneic systems could be mediated through adhesion molecules such as ICAM-1 and LFA-3 on melanoma cells and LFA-1 on T cells. This study suggests that a constellation of cytotoxic effector cells and melanoma-associated antigens may be pivotal in tumor killing. Thus, future adoptive immunotherapy should modulate and enhance this complex interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01525391
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    221. Isoelastische Endoprothese am Schultergelenk (1974)
    Springer
    Langenbeck's archives of surgery 337 (1974), S. 862-862 
    Details
    ISSN: 1435-2451
    Keywords: Shoulder Prosthesis ; Indications ; Fixation ; Isoelastischer Schultergelenkersatz ; Zementlose Fixation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Indikationen zum Einsetzen einer Schulterprothese sind ausgewählte Falls traumatischer Zertrümmerungen des Oberarmkopfes, schmerzhafter posttraumatischer Schulterarthrosen und Kopfnekrosen, Bowie semimaligne und maligns Tumoren des proximalen Oberarmendes, solange noch keine Metastasen bestehen. Die Fixation einer dem Knochen isoelastischen Prothese aus Polyacetalharz ist ohne Knochenzement möglich. Nachuntersuchungen zeigen eine nützliche Schulterfunktion bei eingeschränkter Beweglichkeit.
    Notes: Summary The indications for the implantation of an isoelastic shoulder prosthesis are presented. They are comminution of the humeral head (in carefully selected cases), painful posttraumatic osteoarthritis, and necrosis of the humeral head, and also malignant or benign destructive tumors of the proximal end of the humerus, as long as there are no metastases. An implant made of material of the same degree of elasticity as the bone can be fixed without bone cement. Postoperative check-ups generally show a functionally adequate though restricted range of mobility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01278853
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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