ISSN:
1432-1106
Keywords:
Galanin
;
Spinal cord
;
Flexor reflex
;
Intrathecal
;
Cutaneous afferents
;
Thermoreceptors
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The neuropeptide galanin (GAL) was injected intrathecally (i.t.) in decerebrate, spinalized, unanesthetized rats and its effect on the nocifensive flexor reflex was examined. The reflex, which was evoked by intense mechanical or thermal stimulation of the foot, was recorded from the ipsilateral hamstring muscles. I.t. GAL increased reflex excitability significantly more to thermal than to mechanical stimuli. It is suggested that GAL, which is present in sensory fibers that innervate the skin, is released by the central terminals of cutaneous afferents that are much more sensitive to thermal than to mechanical stimuli.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00248760
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