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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 9 (1972), S. 216-225 
    ISSN: 1432-0827
    Keywords: Osteodystrophy ; Renal ; Histology ; Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Chez 30 patients, présentant une insuffisance rénale, des biopsies de la crête iliaque sont débitées en coupes non décalcifiées pour réaliser une évaluation morphométrique. Le volume de l'os est normal. On note une augmentation du tissue ostéoide et de la résorption osseuse, ainsi qu'une quantité anormale de tissue fibreux. A l'aide de calcul de corrélation et d'analyse de facteurs, quatre facteurs sont choisis. Ils expriment l'influence de l'hormone parathyroidienne sur le tissue osseux, le degré de minéralisation et le rapport entre le volume osseux et la surface osseuse, le rapport entre tissu osseux et espace mesuré, et la résorption osseuse non active.
    Abstract: Zusammenfassung Bei 30 Patienten mit Niereninsuffizienz wurde aus dem Beckenkamm eine Biopsie entnommen und zu Knochenschliffen für morphometrische Messungen verarbeitet. Das Knochenvolumen was normal. Es fand sich ein vergrößerter Anteil an Osteoidgewebe, eine verstärkte Knochenresorption und eine abnormale Menge an fibrösem Gewebe. Mittels Korrelationsberechnungen und Faktoranalysen wurden 4 Faktoren ermittelt, welche folgende Eigenschaften ausdrückten: erstens den Einfluß des Parathormones auf das Knochengewebe, zweitens den Verkalkungsgrad und das Verhältnis zwischen Knochenvolumen und Knochenoberfl;ache, drittens das Verhältnis zwischen Knochengewebe und Zwischenraum und viertens die inaktive Knochenresorption.
    Notes: Abstract In 30 patients with renal insufficiency, a biopsy specimen was taken from the iliac crest and processed to obtain non-decalcified sections for morphometric evaluation. The bone volume was normal. There was an increased amount of osteoid tissue, increased bone resorption and an abnormal amount of fibrous tissue. With the aid of correlation calculations and factor analysis, four factors were extracted which expressed the influence of parathyroid hormone on bone tissue, the degree of mineralization and the relation between bone volume and bone surface, the relation between bone tissue and measured space, and non-active bone resorption.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: Bone Scintigraphy ; Uptake ratio ; Osteoorosis ; Fluoride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The reproducibility and diagnostic value of local bone to soft tissue uptake ratio of99mTc(Sn)-MDP as a bone tracer was examined in a prospective study in 35 patients who were under investigation and/or treatment for postmenopausal osteoporosis. The ratio of tracer uptake in the second lumbar vertebra (L2) and both femoral shafts was calculated from the number of counts in suitable regions of interest. Results obtained with settings and calculations in the routine practice were compared to the results obtained by revision of all raw data in one run by one person. The results were compared to the serum alkaline phosphatase activity (AP) and to local bone mineral mass as determined by dual photon absorptiometry (DPA). In 15 patients serial measurements during fluoride therapy were also compared to serum osteocalcin values and to bone histomorphomatric data. The precision error of the calculation of uptake ratios from raw counts (including selection of region of interest) was 13.9% for the femoral shaft and 14.7% for L2. The mean difference between left and right femoral shaft in individuals was not significant and its variance was smallP 〉 0.1). There was a weak but significant linear correlation between local uptake ratio in the spine and AP in the total material (r=0.328P 〈 0.01). However, changes in local uptake ratio during therapy with fluoride in 15 patients were too small to be of any value and did not correlate with changes in alkaline phosphatase or osteocalcin or trabecular surface covered with osteoblasts. We conclude therefore that local uptake ratio of bone seeking isotopes has no value in assessing general metabolic bone activity in osteoportic patients, for diagnostic purposes or in the follow up of their response to therapy, except for the detection of local untoward reactions.
    Type of Medium: Electronic Resource
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