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  • 1
    Electronic Resource
    Electronic Resource
    Fluoxetine-induced inhibition of male rat copulatory behavior: Modification by lesions of the nucleus paragigantocellularis
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 49 (1994), S. 121-127 
    Details
    ISSN: 0091-3057
    Keywords: Fluoxetine ; Paragigantocellularis ; Serotonin ; Sexual behavior ; Sexual exhaustion
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0091-3057(94)90465-0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Prolonged but not acute fluoxetine administration produces its inhibitory effect on hippocampal seizures in rats (1995)
    Springer
    Psychopharmacology 118 (1995), S. 305-309 
    Details
    ISSN: 1432-2072
    Keywords: Epilepsy ; Serotonin ; Fluoxetine ; Gepirone ; Long-term treatment ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study assessed the effects of acute as well as long-term administration of fluoxetine, a selective serotonin (5-HT) reuptake inhibitor with anti-depressant properties, on hippocampal (HIP) seizures elicited by electrical stimulation in rats. The fluoxetine effect on HIP seizures was also assessed following long-term treatment with gepirone, a 5-HT1A receptor agonist. Acute single administration of fluoxetine (1, 10 mg/kg; IP) was found to produce no significant effect on HIP seizure activity. Following daily IP administration of fluoxetine (10 mg/kg per day) or gepirone (10 mg/kg per day) for 21 days, animals were given a 7-day drug-free period and then challenged with an acute dose of 10 mg/kg fluoxetine. These treatment regimens resulted in a significantly increased afterdischarge threshold of HIP seizures in response to acute fluoxetine administration. The inhibitory effect of fluoxetine, however, was not present 4 weeks after long-term treatment with either fluoxetine or gepirone. The present results indicate that long-term treatment with these compounds enhances the antiepileptic effect of subsequent fluoxetine administration on the generation of HIP seizures. This effect is possibly related to the well-demonstrated evidence that fluoxetine and gepirone, on long-term treatment, facilitate net 5-HT neurotransmission through desensitization of presynaptic 5-HT autoreceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245959
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Online pH,pCO2 andpO2 monitoring system using two-way cyclic pumping of lactate Ringer as a baseline solution (1987)
    Springer
    Medical & biological engineering & computing 25 (1987), S. 45-50 
    Details
    ISSN: 1741-0444
    Keywords: Blood gas ; ISFET ; Lactate Ringer ; Patient monitoring ; pCO2 ; pH ; pO2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A system for the online, simultaneous and intermittent analysis of blood pH, pCO2 pO2 using two-way cyclic pumping of lactate Ringer as a baseline solution is described. The multi-gas sensor is composed of a pH-ISFET with a temperature sensor, a pH-ISFET-based pCO2 sensor and a Clark-type pO2 sensor, bundled in an epoxy rod, and held in place in a flow cell which is directly connectable to an indwelling cannula. The system is controlled by a microcomputer, which supervises pump operation, temperature-compensation of sensor outputs, one-point calibration using sampled blood analysis, and provides graphical display of monitored results. Results of arterial blood-gas monitoring for mongrel dogs are presented which demonstrate the reliability of the present system over extended periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442819
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    Paper (German National Licenses)
    Fulltext
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