ISSN:
1432-0878
Keywords:
Rabbit ovary
;
Follicular development
;
Testosterone immunization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The role of testosterone in follicular development was investigated by immunizing female rabbits (mean wt 1.4 kg) to testosterone-3-bovine serum albumin (T-3-BSA). Controls received BSA. Follicular diameters and histology, and ovarian and uterine weights were recorded at intervals up to 11 weeks. At 5 weeks T-3-BSA ovaries did not differ from controls in either histology or follicular diameter (number of follicles ≥1.0 mm were 12.5±3.4 and 17.0±1.0 for BSA and T-3-BSA treated animals respectively). By 8 weeks T-3-BSA animals had multiple cystic and hemorrhagic follicles. T-3-BSA ovaries contained more follicles ≥1.0〈 1.5 mm (27.3±3.1 vs. 15.3±2.9, P〈0.01) and ≥1.5 mm diameter (5.8±1.7 vs. 0.4±0.3, P〈0.005). At 11 weeks T-3-BSA ovaries contained more follicles 〉 1.5 mm in diameter (5.0±0.9 vs. 0.9±0.3, p〈 0.001). Increased vascularization, some thecal hypertrophy and marked interstitial cell hypertrophy were characteristic of the T-3-BSA ovaries at 8 and 11 weeks. These results suggest that testosterone has a role in the regulation of follicular development.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00225349
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