ISSN:
1432-2072
Keywords:
Δ 9-THC and Δ 8-THC
;
Water Intake
;
Food Intake
;
Body Weight
;
Vocalization
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Water intake was studied in water deprived albino rats at various time intervals after injections of two tetrahydrocannabinols (Δ 9-THC and Δ 8-THC) and solvents. The dose levels used were: 1.25, 2.5, and 5.0 mg/kg of Δ 9-THC and 2.5, 5.0, and 10.0 mg/kg of Δ 8-THC. The results show a clear, dose dependent inhibitory effect on water intake as compared to the controls. Reduced intake of food was seen at 1 day post injection. This effect was, however, significant only for the groups treated with 5.0 and 10.0 mg/kg of Δ 8-THC. A decreased body weight was also recorded after the drug treatment, especially with Δ 8-THC. With respect to cannabis-induced vocalization the data suggest an increased possibility of its appearance with increasing dosages of THC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429190
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