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  • Food interaction  (1)
  • Oxazepam  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Benzodiazepine overdosage: Plasma concentrations and clinical outcome (1981)
    Springer
    Psychopharmacology 73 (1981), S. 381-383 
    Details
    ISSN: 1432-2072
    Keywords: Benzodiazepines ; Diazepam ; Oxazepam ; Overdosage ; Plasma concentration ; Poisoning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma concentrations and their relation to clinical outcome were evaluated in 21 patients who reached emergency treatment facilities following acute overdosage with benzodiazepine derivatives. Diazepam was implicated in 18 of the 21 cases, with plasma diazepam levels ranging from 585–8,635 ng/ml. In four cases of overdosage with diazepam alone, patients were minimally sedated and were discharged within 24 h, despite diazepam doses as high as 750 mg and plasma levels as high as 4,792 ng/ml. However, concurrent ingestion of diazepam together with other central depressant drugs (such as ethanol, barbiturates, analgesics, or tricyclic antidepressants) produced serious intoxication in 5 of the remaining 14 patients, regardless of the diazepam dosage or plasma concentration. Thus the severity of poisoning following benzodiazepine overdosage is determined largely by co-ingestion of other central depressants rather than the amount of benzodiazepine ingested or its concentration in plasma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426470
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Absolute bioavailability of imipramine: Influence of food (1984)
    Springer
    Psychopharmacology 83 (1984), S. 104-106 
    Details
    ISSN: 1432-2072
    Keywords: Imipramine ; Antidepressants ; Pharmacokinetics ; Bioavailability ; Food interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Imipramine hydrochloride (IMI) was administered to 12 healthy volunteers on three occasions in random sequence: 12.5 mg IV, 50 mg orally after overnight fast, and 50 mg orally 30 min after eating a standardized breakfast. IMI concentrations were measured by gas-liquid chromatography using nitrogen-phosphorous detection and pharmacokinetic and bioavailability parameters determined by iterative nonlinear least-squares regression analysis. After IV administration, mean kinetic variables were: volume of distribution, 21.0 l/kg; total clearance, 12.8 ml/min per kg, and elimination half-life, 21.2 h. Mean absolute bioavailability of IMI in the fasting state was 43.6%. When IMI was administered immediately after the standardized meal, absolute bioavailability was 44.1%. After oral administration, the time to peak IMI level was not changed by concurrent food ingestion (2.8 vs 3.2 h after dosage), and the peak IMI concentration was no different (35 vs 30 ng/ml). Thus concurrent food ingestion has no effect on IMI absolute bioavailability, peak concentration attained after oral dosing, or the time to peak concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427432
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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