ISSN:
1432-2013
Keywords:
Free fatty acids
;
Skeletal muscle
;
Membrane conductance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract 1. Na-octanoate (in Ringer's solution) affects the membrane resistance of isolated frog skeletal muscle fibres in a biphasic way. Initially there is an increase followed by a more slowly developing decrease. The effect depends on both the concentration of the fatty acid (1–20 mM) and the time of exposure (2–20 min). 2. In muscles exposed either to isotonic K2SO4 or to Ringer's solution with Cl− substituted by methylsulphate, the octanoate-induced resistance drop is the same as in normal Ringer's solution whereas an initial increase is not observed. 3. In Na-free (Tris-) Ringer's solution, only an increase in membrane resistance is caused by octanoate. 4. The results suggest that Na-octanoate decreases the conductance of the resting muscle cell membrane for anions (Cl−) whereas the permeability for cations (Na+, K+) is increased.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581867
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